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Connections, Cognition and Alzheimer’s Disease

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. B. T. Hayman

    1. Nuerology Service, Massachusetts General Hospital, Boston, USA

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  2. C. Duyckaerts

    1. Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Paris Cedex 16, France

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  3. Y. Christen

    1. Fondation IPSEN, Paris Cedex 16, France

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Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XIII
    Download chapter PDF

  2. Aspects of Cortical Destruction in Alzheimer’s Disease

    • H. Braak, E. Braak
    Pages 1-16

  3. Cortical Feedforward and Cortical Feedback Neural Systems in Alzheimer’s Disease

    • G. W. Van Hoesen
    Pages 17-31

  4. Plaques and Tangles: Where and When?

    • C. Duyckaerts, M.-A. Colle, M. Bennecib, Y. Grignon, T. Uchihara, J.-J. Hauw
    Pages 33-39

  5. Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders

    • P. Vermersch, V. Buée-Scherrer, L. Buée, J. P. David, A. Wattez, N. Sergeant et al.
    Pages 41-52

  6. Neurofibrillary Tangles are Associated with the Differential Loss of Message Expression for Synaptic Proteins in Alzheimer’s Disease

    • Linda Callahan, Paul D. Coleman
    Pages 53-57

  7. Morphologic and Neurochemical Characteristics of Corticocortical Projections: Emergence of Circuit-specific Features and Relationships to Degenerative Changes in Alzheimer’s Disease

    • P. R. Hof, E. A. Nimchinsky, L. G. Ungerleider, J. H. Morrison
    Pages 59-82

  8. Reduced Neuronal Activity is One of the Major Hallmarks of Alzheimer’s Disease

    • D. F. Swaab, P. J. Lucassen, J. A. P. van de Nes, R. Ravid, A. Salehi
    Pages 83-104

  9. Neurodegenerative Alzheimer-like Pathology in PDAPP 717V → F Transgenic Mice

    • D. Games, E. Masliah, M. Lee, K. Johnson-Wood, D. Schenk
    Pages 105-119

  10. Molecular Mechanisms of Synaptic Disconnection in Alzheimer’s Disease

    • E. Masliah, M. Mallory, M. Alford, R. DeTeresa, A. Iwai, T. Saitoh
    Pages 121-140

  11. Is Alzheimer’s Disease Accelerated Aging? Different Patterns of Age and Alzheimer’s Disease-Related Neuronal Losses in the Hippocampus

    • M. J. West, P. D. Coleman, D. G. Flood, J. C. Troncoso
    Pages 141-147

  12. Connections and Cognitive Impairment in Alzheimer’s Disease

    • T. Gomez-Isla, B. T. Hyman
    Pages 149-166

  13. Distributed Hierarchical Neural Systems for Visual Memory in Human Cortex

    • J. V. Haxby, V. P. Clark, M. Courtney
    Pages 167-180

  14. Language and the Alzheimer Brain

    • A. R. Damasio, H. Damasio
    Pages 181-189

  15. Back Matter

    Pages 191-193
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Keywords

About this book

The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. Are neurofibrillary tangles and senile plaques directly related to clinical symptoms, or are they epiphenomena that signal synaptic and neuronal loss? In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation Ipsen which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology. .

Editors and Affiliations

  • Nuerology Service, Massachusetts General Hospital, Boston, USA

    B. T. Hayman

  • Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Paris Cedex 16, France

    C. Duyckaerts

  • Fondation IPSEN, Paris Cedex 16, France

    Y. Christen

Bibliographic Information

  • Book Title: Connections, Cognition and Alzheimer’s Disease

  • Editors: B. T. Hayman, C. Duyckaerts, Y. Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-60680-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-642-64504-4Published: 22 September 2011

  • eBook ISBN: 978-3-642-60680-9Published: 06 December 2012

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XIV, 194

  • Topics: Neurosciences

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