Xenotransplantation

1. Front Matter

   Pages I-XXXIV

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2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction

      • J. L. Platt, E. Kemp, D. K. C. Cooper

      Pages 2-5

3. Immunobiology of Xenograft Rejection

   1. Front Matter

      Pages 7-7

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   2. Hyperacute Xenograft Rejection

      • J. L. Platt

      Pages 8-16

   3. Role of Natural Antibody-Antigen Interactions in Xenotransplantation

      • J. L. Platt, W. Parker, S. S. Lin, Z. Holzknecht, S. Saadi

      Pages 17-23

   4. Major Carbohydrate Xenotransplantation Antigens

      • R. Oriol, D. K. C. Cooper

      Pages 24-32

   5. Natural Antibody Polymorphism and Anti-Galα1–3Gal Antibodies

      • T. D. H. Cairns, J. Lee, L. C. Goldberg, B. E. Samuelsson, D. H. Taube

      Pages 33-37

   6. Role of Complement in Xenograft Rejection

      • A. P. Dalmasso

      Pages 38-60

   7. Genetic Control of Humoral Responses to Xenografts

      • D. V. Cramer

      Pages 61-76

   8. Mechanisms of Delayed Xenograft Rejection

      • D. J. Goodman, M. T. Millan, C. Ferran, F. H. Bach

      Pages 77-94

   9. Anti-αgalactosyl (Anti-Gal) Antibody Damage Beyond Hyperacute Rejection

      • U. Galili

      Pages 95-103

   10. Human Natural Killer Cells and Natural Antibodies Recognize Overlapping Molecular Structures on Discordant Xenogeneic Endothelium

       • L. Inverardi, R. Pardi

       Pages 104-125

   11. Hemostasis in Xenotransplantation

       • B. J. Hunt, K. M. Jurd

       Pages 126-139

   12. Mechanism of Cellular Xenograft Rejection

       • R. D. Moses, H. Auchincloss Jr.

       Pages 140-174

   13. Human T Cell Response to Porcine Tissues

       • M. L. Rose

       Pages 175-189

   14. Cellular Interactions in Discordant Xenotransplantation

       • S. A. Rollins, L. A. Matis

       Pages 190-198

   15. Immunoprivileged Sites for Allo-and Xenotransplantation

       • J. H. Dinsmore

       Pages 199-205

   16. Immunobiology of Xenotransplantation in Rodents

       • F. T. Thomas, W. Marchman, A. Carobbi, J. Contreras, J. George, E. Larkin et al.

       Pages 206-225

4. Pathology of Xenograft Rejection

   1. Front Matter

      Pages 227-227

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This is a time ofexcitement and progress in the field ofxenotransplantation. The work described in this book traces the development of the science of cross-spe­ cies transplantation, summarizes the current state ofour knowledge, and focuses on approaches directed toward future clinical application. The important question is not whether xenotransplantation will succeed, but rather how and under what circumstances xenografts will provide predictable enough results to warrant clinical application. The fact that the best results to date in clinical xenografting were achieved over three decades ago should not be a matter of discouragement, but rather a stimulus to apply new approaches to this area of work. The shortage of human organs for transplantation is cited frequently as the driving force behind the increased interest in xenotransplantation. This shortage is an undeniable fact, but there are additional potential advantages of xenotrans­ plantation, such as the ability to schedule replacement surgery on an elective basis and the modification of animals, organs, and tissues to improve acceptabil­ ity in the human host. The advances in the basic science ofxenotransplantation outlined in this book give hope that the immunologic barriers to xenotransplantation will be overcome and that transplanted organs and tissues will succeed consistently in humans. However, if our experience with human allografts provides an analogy, we may anticipate that clinical progress in xenografts will be plagued by failures and rewarded by successes, often without a complete understanding of the mechan­ isms involved.

• Genetic Engineering
• Heterografting
• Heterotransplantation
• Immunbiologie
• Transplantation
• Transplantationsimmunologie
• Xenogr
• experimental surgery
• experimentelle Chirurgie
• glycobiology
• immunobiology
• organ transplantation
• transplantation immunology

"The new, revised and extended second edition provides a complete overview of this promising and exciting field. This work uniquely puts into perspective the essential features of xenotransplantation and its, as yet, unresolved problems." Transplant International

• Immunologist (Surgery), Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA

  David K. C. Cooper

• Oklahoma Medical Research Foundation, Oklahoma City, USA

  David K. C. Cooper

• Department of Nephrology, Odense University Hospital, Odense, Denmark

  Ejvind Kemp

• Departments of Surgery, Pediatrics and Immunology, Duke University Medical Center, Durham, USA

  Jeffrey L. Platt

• Department of Surgery, University of Cambridge, Cambridge, UK

  David J. G. White

• Imutran Laboratories, Cambridge, UK

  David J. G. White

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