Mechanisms of B Cell Neoplasia 1998

1. Front Matter

   Pages I-XXIX

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2. B Cell and Plasma Cell Development

   1. Front Matter

      Pages 1-1

      PDF

   2. The Formation and Selection of Cells Expressing PreB Cell Receptors and B Cell Receptors

      • E. ten Boekel, T. Yamagami, J. Andersson, A. G. Rolink, F. Melchers

      Pages 3-10

   3. Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development

      • R. Ceredig, A. G. Rolink, F. Melchers, J. Andersson

      Pages 11-19

   4. Negative Selection of Self-reactive B Lymphocytes Involves Complement

      • M. Carroll

      Pages 21-29

   5. Cross-talk Between CD44 and c-Met in B cells

      • T. E. I. Taher, R. van der Voort, L. Smit, R. M. J. Keehnen, E. J. M. Schilder-Tol, M. Spaargaren et al.

      Pages 31-38

   6. The Transition from Immature to Mature B Cells

      • A. G. Rolink, F. Melchers, J. Andersson

      Pages 39-44

   7. CD21highIgMhigh Splenic B Cells Enriched in the Marginal Zone: Distinct Phenotypes and Functions

      • F. Martin, J. F. Kearney

      Pages 45-52

   8. Do Germinal Centers Have a Role in the Generation of Lymphomas?

      • K. Yang, M. Davila, G. Kelsoe

      Pages 53-62

   9. Role of Complement Receptors CD21/CD35 in B Lymphocyte Activation and Survival

      • M. Carroll

      Pages 63-69

   10. Long-lived Plasma Cells Survive Independent of Antigen

       • R. A. Manz, G. Cassese, A. Thiel, A. Radbruch

       Pages 71-75

3. Chemokines and Chemokine Receptors

   1. Front Matter

      Pages 77-77

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   2. Regulation of Expression of Chemokine Receptor BLR1/CXCR5 during B Cell Maturation

      • V. Pevzner, I. Wolf, R. Burgstahler, R. Förster, M. Lipp

      Pages 79-85

   3. Chemokines and B-cell Homing to Follicles

      • J. G. Cyster, V. N. Ngo, E. H. Ekland, M. D. Gunn, J. D. Sedgwick, K. M. Ansel

      Pages 87-93

   4. A Novel CC Chemokine ABCD-1, Produced by Dendritic Cells and Activated B Cells, Exclusively Attracts Activated T Lymphocytes

      • C. Schaniel, F. Sallusto, P. Sideras, F. Melchers, A. G. Rolink

      Pages 95-101

   5. Human Macrophage-Derived Chemokine (MDC) is Strongly Expressed Following Activation of both Normal and Malignant Precursor and Mature B Cells

      • P. Ghia, C. Schaniel, A.G Rolink, L. M. Nadler, A. A. Cardoso

      Pages 103-110

   6. Susceptibility Genes for AIDS and AIDS-Related Lymphoma

      • C. S. Rabkin, S. Sei

      Pages 111-115

   7. Molecular Mechanisms of T Helper Cell Differentiation and Tissue-specific Migration

      • D. D’Ambrosio, P. Panina-Bordignon, L. Rogge, F. Sinigaglia

      Pages 117-122

   8. The Role of Chemokine Receptors in Directing Traffic of Naive, Type 1 and Type 2 T Cells

      • F. Sallusto, B. Palermo, A. Hoy, A. Lanzavecchia

      Pages 123-129

   9. A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids

      • Markus H. Gräler, Günter Bernhardt, Martin Lipp

      Pages 131-137

Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog­ ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri­ ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol­ ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen­ eral topics and themes, the papers are organized into five sec­ tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.

• AIDS
• Chemokine
• DNA
• apoptosis
• autoimmunity
• bacteria
• cell
• immunity
• leukemia
• lymphocytes
• lymphoma
• mutagen
• pathogenesis
• prevention
• virus

• Basel Institute for Immunology, Basel, Switzerland

  Fritz Melchers

• Laboratory of Genetics Building 37, Room 2B04, National Cancer Institute National Institutes of Health, Bethesda, USA

  Michael Potter

Policies and ethics