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  • Conference proceedings
  • © 2003

Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders

Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (10 papers)

  1. Front Matter

    Pages I-XIV
  2. Characterization of Amyloid Beta Vaccination Strategies in Mice

    • C. Cao, K. E. Ugen, C. Dickey, D. Wilcock, Y. Bai, M. N. Gordon et al.
    Pages 21-31
  3. Cognitive Characteristics of TgAPP CRND8 Mice Immunised with Beta Amyloid Peptide

    • C. Janus, H.-S. Johnson, J. McLaurin, P. Fraser, P. St. George-Hyslop, D. Westaway
    Pages 33-43
  4. Improvements in Intranasal Amyloid-β (Aβ) Immunization in Mice

    • C. A. Lemere, E. T. Spooner, J. F. Leverone, J. D. Clements
    Pages 59-74
  5. Antibody Therapy Against β-Amyloid to Treat Alzheimer’s Disease

    • F. Bard, P. Seubert, D. Schenk, T. Yednock
    Pages 75-83
  6. Effects of a Peripheral Anti-Aβ Antibody on Plasma and CNS Aβ Clearance

    • D. M. Holtzman, K. R. Bales, S. M. Paul, R. B. DeMattos
    Pages 85-95
  7. Antibodies as Therapeutic Agents for Prion Disease

    • D. Peretz, R. A. Williamson, K. Kaneko, D. R. Burton, S. B. Prusiner
    Pages 107-123
  8. Back Matter

    Pages 125-126

About this book

Promising effects in mice of immunization by ß-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer's disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors' objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available information and the questions it raises.

Editors and Affiliations

  • Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA

    Dennis J. Selkoe

  • Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

    Yves Christen

Bibliographic Information

  • Book Title: Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders

  • Editors: Dennis J. Selkoe, Yves Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-642-59332-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2003

  • Softcover ISBN: 978-3-642-63937-1Published: 18 September 2011

  • eBook ISBN: 978-3-642-59332-1Published: 06 December 2012

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: VIII, 130

  • Number of Illustrations: 11 illustrations in colour

  • Topics: Neurology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access