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Pharmacology of Ionic Channel Function: Activators and Inhibitors

  • Book
  • © 2000

Overview

Editors:
  1. Makato Endo

    1. Saitama Medical School, Saitama, Japan

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  2. Yoshihisa Kurachi

    1. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, Osaka, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. Masayoshi Mishina

    1. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • This book is unique in that it provides a comprehensive review of these vitally important ion channels with detailed descriptions of the molecular structure and function and expecially of activators and inhibitors
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 147)

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Table of contents (25 chapters)

  1. Front Matter

    Pages I-XXXI
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  2. Voltage-Dependent Ion Channels A. Voltage-Dependent na Channels

    1. Front Matter

      Pages 1-1
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    2. Structure and Functions of Voltage-Dependent Na+ Channels

      • K Imoto
      Pages 3-26

    3. Sodium Channel Blockers and Activators

      • A. O. Grant
      Pages 27-51

    4. Classification and Function of Voltage-Gated Calcium Channels

      • J. B. Bergsman, D. B. Wheeler, R. W. Tsien
      Pages 55-85

    5. Structure of the Voltage-Dependent L-Type Calcium Channel

      • F. Hofmann, N. Klugbauer
      Pages 87-117

    6. Ca2+Channel Antagonists and Agonists

      • S Adachi-Akahane, T. Nagao
      Pages 119-154

    7. Overview of Potassium Channel Families: Molecular Bases of the Functional Diversity

      • Y. Kubo
      Pages 157-176

    8. Pharmacology of Voltage-Gated Potassium Channels

      • O. Pongs, C. Legros
      Pages 177-196

    9. Voltage-Gated Calcium-Modulated Potassium Channels of Large Unitary Conductance: Structure, Diversity, and Pharmacology

      • R. Latorre, C. Vergara, O. Alvarez, E. Stefani, L. Toro
      Pages 197-223

    10. Classical Inward Rectifying Potassium Channels: Mechanisms of Inward Rectification

      • C. G. Nichols
      Pages 225-242

    11. ATP-Dependent Potassium Channels in the Kidney

      • G. Giebisch, W. Wang, S. C. Hebert
      Pages 243-270

    12. Structure and Function of ATP-Sensitive K+ Channels

      • T. Gonoi, S. Seino
      Pages 271-295

    13. G Protein-Gated K+ Channels

      • A. Inanobe, Y. Kurachi
      Pages 297-331

    14. Potassium Channels with Two Pore Domains

      • F. Lesage, M. Lazdunski
      Pages 333-345

    15. Cardiac K+ Channels and Inherited Long QT Syndrome

      • M.-D. Drici, J. Barhanin
      Pages 347-362

  3. Ligand Operated Ion Channels

    1. Front Matter

      Pages 363-363
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    2. Gating of Ion Channels by Transmitters: The Range of Structures of the Transmitter-Gated Channels

      • A. E. Barnard
      Pages 365-392

    3. Molecular Diversity, Structure, and Function of Glutamate Receptor Channels

      • M. Mishina
      Pages 393-414

    4. Glutamate Receptor Ion Channels: Activators and Inhibitors

      • D. E. Jane, H. W. Tse, D. A. Skifter, J. M. Christie, D. T. Monaghan
      Pages 415-478
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Keywords

About this book

Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.

Editors and Affiliations

  • Saitama Medical School, Saitama, Japan

    Makato Endo

  • Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, Osaka, Japan

    Yoshihisa Kurachi

  • Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Tokyo, Japan

    Masayoshi Mishina

Bibliographic Information

  • Book Title: Pharmacology of Ionic Channel Function: Activators and Inhibitors

  • Editors: Makato Endo, Yoshihisa Kurachi, Masayoshi Mishina

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-57083-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-66127-6Published: 26 July 2000

  • Softcover ISBN: 978-3-642-63030-9Published: 24 September 2012

  • eBook ISBN: 978-3-642-57083-4Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXXI, 662

  • Number of Illustrations: 105 b/w illustrations, 2 illustrations in colour

  • Topics: Biochemistry, general, Pharmacology/Toxicology, Human Physiology, Cell Biology

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