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Transgenic Models in Pharmacology

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 159)

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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XI
  2. Molecular Systems

    1. Front Matter

      Pages 31-31
    2. Adrenergic System

      • S. Engelhardt, L. Hein
      Pages 33-63
    3. Muscarinic Acetylcholine Receptor Knockout Mice

      • J. Wess, W. Zhang, A. Duttaroy, T. Miyakawa, J. Gomeza, Y. Cui et al.
      Pages 65-93
    4. Mouse Models of NO/Natriuretic Peptide/cGMP Kinase Signaling

      • F. Hofmann, M. Biel, R. Feil, T. Kleppisch
      Pages 95-130
    5. G Protein-Mediated Signalling Pathways

      • S. Offermanns
      Pages 165-192
    6. Analysis of Integrin Function by Gene Targeting in Mice

      • O. Brandau, R. Fässler
      Pages 193-225
  3. Nervous System

    1. Front Matter

      Pages 227-227
    2. Neurotrophic Factors

      • M. Sendtner
      Pages 285-310
    3. Genetic Analysis of the Endogenous Opioid System

      • J. E. Pintar, B. L. Kieffer
      Pages 311-342
  4. Cardiovascular System

    1. Front Matter

      Pages 343-343
    2. Transgenic Mouse Models of Cardiovascular Function and Disease

      • W. J. Koch, B. C. Blaxall
      Pages 345-367
    3. Lipoprotein Transport

      • H. H. Bock, P. May, J. Herz
      Pages 397-421
  5. Immunology/Hematology/Inflammation

    1. Front Matter

      Pages 423-423

About this book

The aim of this volume is to give up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at  illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.

 

Editors and Affiliations

  • Pharmakologisches Institut, Universität Heidelberg, Heidelberg, Germany

    Stefan Offermanns

  • Institut für Pharmakologie und Toxikologie der Universität, Germany

    Lutz Hein

Bibliographic Information

  • Book Title: Transgenic Models in Pharmacology

  • Editors: Stefan Offermanns, Lutz Hein

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-18934-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2004

  • Hardcover ISBN: 978-3-540-00109-6Published: 10 October 2003

  • Softcover ISBN: 978-3-642-62362-2Published: 09 October 2012

  • eBook ISBN: 978-3-642-18934-0Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XVIII, 280

  • Topics: Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access