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Superantigens

  • Book
  • © 1991

Overview

Editors:
  1. Bernhard Fleischer

    1. Pathophysiology Section, First Department of Medicine, University of Mainz, Mainz, Germany

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  2. Hans Olov Sjögren

    1. Wallenberg Laboratory, University of Lund, Lund, Sweden

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 174)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-IX
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  2. Molecular Genetics of Pyrogenic Exotoxin “Superantigens” of Group A Streptococci and Staphylococcus aureus

    • P. K. Lee, P. M. Schlievert
    Pages 1-19

  3. T Cell Recognition of Superantigens

    • T. Herrmann, H. R. MacDonald
    Pages 21-38

  4. T Cell Activation by Superantigens—Dependence on MHC Class II Molecules

    • H. O. Sjögren
    Pages 39-51

  5. The Human T Cell Response to Mitogenic Microbial Exotoxins

    • B. Fleischer
    Pages 53-62

  6. Toxic Shock Syndrome Toxin-1, Toxic Shock, and the Immune System

    • T. Chatila, P. Scholl, F. Spertini, N. Ramesh, N. Trede, R. Fuleihan et al.
    Pages 63-79

  7. Staphylococcal Enterotoxin-Dependent Cell-Mediated Cytotoxicity

    • T. Kalland, G. Hedlund, M. Dohlsten, P. A. Lando
    Pages 81-92

  8. CD4/CD8 Coreceptor-Independent Costimulator-Dependent Triggering of SEB-Reactive Murine T Cells

    • K. Heeg, T. Miethke, P. Bader, S. Bendigs, C. Wahl, H. Wagner
    Pages 93-106

  9. The Immunobiology of Mycoplasma arthritidis and its Superantigen MAM

    • B. C. Cole
    Pages 107-119

  10. The Anti-CD3-Induced Syndrome: A Consequence of Massive In Vivo Cell Activation

    • L. Chatenoud, C. Ferran, J.-F. Bach
    Pages 121-134

  11. Back Matter

    Pages 135-140
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Keywords

About this book

This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen­ ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.

Editors and Affiliations

  • Pathophysiology Section, First Department of Medicine, University of Mainz, Mainz, Germany

    Bernhard Fleischer

  • Wallenberg Laboratory, University of Lund, Lund, Sweden

    Hans Olov Sjögren

Bibliographic Information

  • Book Title: Superantigens

  • Editors: Bernhard Fleischer, Hans Olov Sjögren

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-50998-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1991

  • Softcover ISBN: 978-3-642-51000-7Published: 26 May 2012

  • eBook ISBN: 978-3-642-50998-8Published: 09 March 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 137

  • Number of Illustrations: 5 b/w illustrations

  • Topics: Allergology, Immunology, Medical Microbiology, Internal Medicine

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