Genes and Environment in Cancer

1. Front Matter

   Pages I-XIV

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2. Key Notes

   1. Front Matter

      Pages 1-1

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   2. Epidemiological Evidence of the Effects of Behaviour and the Environment on the Risk of Human Cancer

      • R. Doll

      Pages 3-21

   3. Molecular Epidemiology of Human Cancer

      • S. P. Hussain, C. C. Harris

      Pages 22-36

3. Risk Assessment and DNA Lesions

   1. Front Matter

      Pages 37-37

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   2. Molecular Epidemiology of Environmental Carcinogenesis

      • F. P. Perera

      Pages 39-46

   3. Polymorphisms of N-Acetyltransferases, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility

      • J. G. Hengstler, M. Arand, M. E. Herrero, F. Oesch

      Pages 47-85

   4. Impact of Adduct Determination on the Assessment of Cancer Susceptibility

      • H. Bartsch, M. Rojas, K. Alexandrov, A. Risch

      Pages 86-96

   5. Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes

      • E. Dogliotti, P. Hainaut, T. Hernandez, M. D’Errico, D. M. Demarini

      Pages 97-124

4. DNA Repair and Genetic Susceptibility

   1. Front Matter

      Pages 125-125

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   2. Relevance of DNA Repair to Carcinogenesis and Cancer Therapy

      • M. F. Rajewsky, J. Engelbergs, J. Thomale, T. Schweer

      Pages 127-146

   3. Molecular Basis of DNA Repair Mechanisms and Syndromes

      • G. Weeda, J. de Boer, I. Donker, J. de Wit, S. B. Winkler, G. T. J. van der Horst et al.

      Pages 147-155

   4. The Ataxia Telangiectasia Gene in Familial and Sporadic Cancer

      • M. A. R. Yuille, L. J. A. Coignet

      Pages 156-173

5. Induced Chromosome Damage and Cancer

   1. Front Matter

      Pages 175-175

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   2. Cancer Predictive Value of Cytogenetic Markers Used in Occupational Health Surveillance Programs

      • L. Hagmar, S. Bonassi, U. Strömberg, Z. Mikoczy, C. Lando, I.-L. Hansteen et al.

      Pages 177-184

   3. Instability at Chromosomal Fragile Sites

      • T. W. Glover

      Pages 185-199

   4. The Role of Deletions at the FRA3B/FHIT Locus in Carcinogenesis

      • K. Huebner, T. Druck, Z. Siprashvili, C. M. Croce, A. Kovatich, P. A. McCue

      Pages 200-215

   5. Gene Amplification Mechanisms: The Role of Fragile Sites

      • M. Debatisse, A. Coquelle, F. Toledo, G. Buttin

      Pages 216-226

6. Genetic Susceptibility and Environmental Exposure: “The RET Paradigm”

   1. Front Matter

      Pages 227-227

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   2. Mechanisms of Development of Multiple Endocrine Neoplasia Type 2 and Hirschsprung’s Disease by ret Mutations

      • M. Takahashi, N. Asai, T. Iwashita, H. Murakami, S. Ito

      Pages 229-236

Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as "cancer".

• DNA
• Genetik
• Termination
• breast cancer
• cancer
• cancer therapy
• carcinogenesis
• carcinoma
• chromosome
• colorectal cancer
• epidemiology
• genes
• genetics
• molecular genetics
• tumor

• Abteilung Zytogenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

  Manfred Schwab

• Pathologisches Institut, Universität München, München, Germany

  Hartmut M. Rabes

• Deutsches Krebsforschungszentrum, Heidelberg, Germany

  Klaus Munk

• Max-Planck-Institut für Biochemie, Martinsried, Germany

  Hans Peter Hofschneider

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