Bradykinin, Kallidin and Kallikrein

1. Front Matter

   Pages I-XIX

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2. Introduction

   1. Discovery of the Most Important Kallikreins and Kallikrein Inhibitors

      • Eugen Werle

      Pages 1-6

   2. The Discovery and Characterization of Bradykinin

      • D. F. Elliott

      Pages 7-13

3. Methods Used in Kinin Research

   1. The Kinins: Methods of Chemical Synthesis

      • J. M. Stewart

      Pages 14-20

   2. Purification of Mammalian Kallikreins, Kininogens, and Kinins

      • Jack V. Pierce

      Pages 21-51

   3. Assay Methods in the Kinin System

      • Ivar Trautschold

      Pages 52-81

4. Kininogenases

   1. Plasma Kininogenases and Their Activators

      • V. Eisen, W. Vogt

      Pages 82-130

   2. Kallikreins in Glandular Tissues

      • Marion E. Webster

      Pages 131-155

   3. Proteolytic Enzymes as Kininogenases

      • J. L. Prado

      Pages 156-192

   4. Snake Venoms

      • Tomoji Suzuki, Sadaaki Iwanaga

      Pages 193-212

   5. Kallikrein Inhibitors

      • Rosmarie Vogel, Eugen Werle

      Pages 213-249

5. Kininogens

   1. Kininogens

      • E. Habermann

      Pages 250-288

6. Kininases

   1. Kininases

      • E. G. Erdös, H. Y. T. Yang

      Pages 289-323

7. Kinins

   1. Physiological and Pharmacological Actions

      1. Structure-Activity Relationships of Kinins

         • E. Schröder

         Pages 324-350

      2. Effect of Kallikrein on the Cardiovascular System

         • Gerhard A. Brecher, Günther F. Brobmann

         Pages 351-361

      3. The Effect of the Kinins on the Cardiovascular System

         • F. J. Haddy, T. E. Emerson Jr., J. B. Scott, R. M. Daugherty Jr.

         Pages 362-384

      4. Effects of Bradykinin on the Kidney and Gastrointestinal Organs

         • Eugene D. Jacobson

         Pages 385-388

      5. The Physiological Role of Glandular Kallikreins

         • S. M. Hilton

         Pages 389-399

      6. Vasodilatation in the Submaxillary Gland of the Cat, Rabbit, and Sheep

         • M. Schachter

         Pages 400-408

      7. Kinins and Ventilation of the Lungs

         • H. O. J. Collier

         Pages 409-420

Bradykinin is frequently referred to as an elusive substance; the editor of a comprehensive volume dealing with kinins thus has a difficult task. The com­ plexity of the issues calls for a large number of contributors who approach the topics from the various angles that are dictated by the sometimes divergent views of the individuals. The editor saw no reason to prescribe the mode of presentation, which was left to the authors and accounts for the variety of approaches. Contributors from nine countries were asked to participate in the volume. The chapters were organized to present, first, the history of the discoveries and methods of approach to kinin research. Then follows a discussion of the enzymes that release kinins, their substrates, and other enzymes that inactivate the peptides. If the release of kinin is important, then the inhibition of the releasing enzymes is of obvious interest and is described. Since the measurement of kinin­ ogen levels in blood has been frequently used as an indicator of kinin liberation, in addition to a separate chapter, kininogens are also mentioned where the functions of kinins are discussed. The conclusions drawn from establishing structure-action relationships for many analogs and the actions of kinins are indicated and summarized.

• Respiration
• antibody
• assessment
• central nervous system
• chemistry
• chromatography
• heart
• inflammation
• kidney
• nervous system
• pathology
• pharmacodynamics
• pharmacology
• research
• therapy

• Department of Pharmacology, University of Oklahoma Medical Center, Oklahoma City, USA

  Ervin G. Erdös

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