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Antiplatelet Agents

  • Book
  • © 2012

Overview

Editors:
  1. Paolo Gresele

    1. , Department of Internal Medicine, University of Perugia, Perugia, Italy

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  2. Gustav V. R Born

    1. Institute, The William Harvey Research, London, United Kingdom

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  3. Carlo Patrono

    1. Istituto di Farmacologia, Università Cattolica del S. Cuore, Roma, Italy

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  4. Clive P. Page

    1. King's College London, Sackler Inst. Pulmonary Pharmacology, London, United Kingdom

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  • Written by leading experts in the field
  • With numerous illustrations
  • Gives an overview on the current state of the art
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 210)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xii
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  2. Pathophysiology

    1. Front Matter

      Pages 1-1
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    2. Platelets: Production, Morphology and Ultrastructure

      • Jonathan N. Thon, Joseph E. Italiano
      Pages 3-22

    3. Platelet Receptors

      • Alexandre Kauskot, Marc F. Hoylaerts
      Pages 23-57

    4. Platelet Signaling

      • Timothy J. Stalker, Debra K. Newman, Peisong Ma, Kenneth M. Wannemacher, Lawrence F. Brass
      Pages 59-85

    5. Platelet Interaction with the Vessel Wall

      • Philip G. de Groot, Rolf T. Urbanus, Mark Roest
      Pages 87-110

    6. Platelets in Atherosclerosis and Thrombosis

      • Christian Schulz, Steffen Massberg
      Pages 111-133

  3. Pharmacology

    1. Front Matter

      Pages 135-135
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    2. Aspirin and Other COX-1 Inhibitors

      • Carlo Patrono, Bianca Rocca
      Pages 137-164

    3. Thienopyridines and Other ADP-Receptor Antagonists

      • Isabell Bernlochner, Dirk Sibbing
      Pages 165-198

    4. Glycoprotein IIb/IIIa Antagonists

      • Karen M. Hook, Joel S. Bennett
      Pages 199-223

    5. Targeting Phosphodiesterases in Anti-platelet Therapy

      • Matthew T. Rondina, Andrew S. Weyrich
      Pages 225-238

    6. PAR-1 Inhibitors: A Novel Class of Antiplatelet Agents for the Treatment of Patients with Atherothrombosis

      • Sergio Leonardi, Richard C. Becker
      Pages 239-260

    7. Thromboxane Receptors Antagonists and/or Synthase Inhibitors

      • Giovanni Davì, Francesca Santilli, Natale Vazzana
      Pages 261-286

    8. Inhibitors of the Interaction Between von Willebrand Factor and Platelet GPIb/IX/V

      • Paolo Gresele, Stefania Momi
      Pages 287-309

    9. Inhibitors of the Interactions Between Collagen and Its Receptors on Platelets

      • Hans Deckmyn, Simon F. De Meyer, Katleen Broos, Karen Vanhoorelbeke
      Pages 311-337

    10. Intracellular Signaling as a Potential Target for Antiplatelet Therapy

      • Patrick Andre
      Pages 339-367

    11. Novel Targets for Platelet Inhibition

      • Kathleen Freson, Chris Van Geet
      Pages 369-394

    12. Variability of Platelet Indices and Function: Acquired and Genetic Factors

      • Giovanni de Gaetano, Iolanda Santimone, Francesco Gianfagna, Licia Iacoviello, Chiara Cerletti
      Pages 395-434

    13. Small RNAs as Potential Platelet Therapeutics

      • Leonard C. Edelstein, Paul F. Bray
      Pages 435-445
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Keywords

About this book

Antiplatelet therapy is the cornerstone of treatment of ischemic cardiovascular disease and over the last few years spectacular advancements in this field have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysiology, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different European countries and from the USA, both from academia and industry, have contributed to the book. Besides a detailed overview on the pharmacology and clinical applications of all the currently used or of the novel antiplatelet agents, innovative approaches (e.g. intracellular signalling as an antiplatelet target, small RNAs as platelet therapeutics, etc.) or unconventional aspects (e.g. pharmacologic modulation of the inflammatory action of platelets are also treated. The book is oriented to both basic investigators and to clinicians involved with research on platelet inhibition or with the clinical use of antiplatelet therapies.

Editors and Affiliations

  • , Department of Internal Medicine, University of Perugia, Perugia, Italy

    Paolo Gresele

  • Institute, The William Harvey Research, London, United Kingdom

    Gustav V. R Born

  • Istituto di Farmacologia, Università Cattolica del S. Cuore, Roma, Italy

    Carlo Patrono

  • King's College London, Sackler Inst. Pulmonary Pharmacology, London, United Kingdom

    Clive P. Page

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