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From Nucleic Acids Sequences to Molecular Medicine

  • Book
  • © 2012

Overview

Editors:
  1. Volker A. Erdmann

    1. Institute of Chemistry/Biochemistry, Free University Berlin, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Jan Barciszewski

    1. Inst. Bioorganic Chemistry, PAN Poznan, Poznan, Poland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • The book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine
  • Written by leading experts in the field
  • With numerous illustrations
  • Includes supplementary material: sn.pub/extras

Part of the book series: RNA Technologies (RNATECHN)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-ix
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  2. RNAissance

    • Juergen Brosius
    Pages 1-18

  3. Nucleic Acids as Therapeutics

    • Saraswat Pushpendra, Pareek Arvind, Bhandari Anil
    Pages 19-45

  4. Thio Effects as a Tool for Mechanistic Studies of the Cleavage of RNA Phosphodiester Bonds: The Chemical Basis

    • Mikko Ora, Tuomas Lönnberg, Harri Lönnberg
    Pages 47-65

  5. Off-Target Effects and Safety Aspects of Phosphorothioate Oligonucleotides

    • Martina Stessl, Christian R. Noe, Johannes Winkler
    Pages 67-83

  6. Oligonucleotide Conjugates: Rationale, Synthesis, and Applications

    • Yashveer Singh, Pierre Murat, Nicolas Spinelli, Eric Defrancq
    Pages 85-120

  7. CRISPR: A Bacterial Immunity System Based on Small RNAs

    • Rolf Wagner, Ümit Pul
    Pages 121-143

  8. Antisense Technology: From Unique Laboratory Tool to Novel Anticancer Treatments

    • Christine Di Cresce, Colin Way, Mateusz Rytelewski, Saman Maleki Vareki, Supritha Nilam, Mark D. Vincent et al.
    Pages 145-189

  9. Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs

    • Xue-hai Liang, Timothy A. Vickers, Stanley T. Crooke
    Pages 191-214

  10. Antisense Oligonucleotides in the Treatment of Malignant Gliomas

    • Gerardo Caruso, Mariella Caffo, Giuseppe Raudino, Federica Raudino, Mario Venza, Francesco Tomasello
    Pages 215-246

  11. Natural Antisense Transcripts Mediate Regulation of Gene Expression

    • Marco Magistri, Mohammad Ali Faghihi
    Pages 247-274

  12. Activation and Deactivation of Antisense and RNA Interference Function with Light

    • Jeane M. Govan, Alexander Deiters
    Pages 275-291

  13. Ribozymes as Molecular Biology Reagents

    • Sanchita Bhadra, Arti Pothukuchy, Andrew Ellington
    Pages 293-312

  14. RNA Technologies for Mitochondrial Genetics

    • André Dietrich, Katarzyna Rolle, Marta Gabryelska, Eliza Wyszko, Romain Val, Maciej Szymanski et al.
    Pages 313-356

  15. RNA-Based Therapies for Inherited Metabolic Diseases

    • Belén Pérez, Magdalena Ugarte, Lourdes R. Desviat
    Pages 357-370

  16. RNA-Cleaving DNA Enzymes and Their Potential Therapeutic Applications as Antibacterial and Antiviral Agents

    • P. I. Pradeepkumar, Claudia Höbartner
    Pages 371-410

  17. Hammerhead Ribozymes Against Virus and Viroid RNAs

    • Alberto Carbonell, Ricardo Flores, Selma Gago
    Pages 411-427

  18. Suppression of Hepatitis C Viral Genome Replication with RNA-Cleaving Deoxyribozyme

    • Dal-Hee Min, Dong-Eun Kim
    Pages 429-452

  19. Design of Synthetic shRNAs for Targeting Hepatitis C: A New Approach to Antiviral Therapeutics

    • Brian H. Johnston, Qing Ge
    Pages 453-473

  20. The Diverse Active Sites in Splicing, Debranching, and MicroRNA Processing Around RNA Phosphodiester Bonds

    • Sourav Kumar Dey, Eduardo Paredes, Molly Evans, Subha R. Das
    Pages 475-501
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Keywords

About this book

Despite a half century of structural, biophysical and biochemical investigations of ribonucleic acids, they are still mysterious. RNAs stand at fertile crossroads of disciplines, integrating concepts from genomics, proteomics, dynamics as well as biochemistry and molecular biology. From 20 years it is clear, that genetic regulation of eukaryotic organisms has been misunderstood for the last years that the expression of genetic information is effected only by proteins. Basic understanding of nucleic acids has enhanced our foundation to probe novel biological functions. This is especially evident for RNA molecules whose functionality, maturation, and regulation require formation of correct secondary structure through encoded base-pairing interactions.

Editors and Affiliations

  • Institute of Chemistry/Biochemistry, Free University Berlin, Berlin, Germany

    Volker A. Erdmann

  • Inst. Bioorganic Chemistry, PAN Poznan, Poznan, Poland

    Jan Barciszewski

Bibliographic Information

  • Book Title: From Nucleic Acids Sequences to Molecular Medicine

  • Editors: Volker A. Erdmann, Jan Barciszewski

  • Series Title: RNA Technologies

  • DOI: https://doi.org/10.1007/978-3-642-27426-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2012

  • Hardcover ISBN: 978-3-642-27425-1Published: 14 June 2012

  • Softcover ISBN: 978-3-642-43083-1Published: 18 July 2014

  • eBook ISBN: 978-3-642-27426-8Published: 13 June 2012

  • Series ISSN: 2197-9731

  • Series E-ISSN: 2197-9758

  • Edition Number: 1

  • Number of Pages: X, 654

  • Topics: Molecular Medicine, Nucleic Acid Chemistry, Human Genetics

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