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Molecular Biology of the SARS-Coronavirus

  • Book
  • © 2010

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Editors:
  1. Sunil K. Lal

    1. Engineering & Biotechnology, International Centre for Genetic, New Delhi, India

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiii
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  3. Structures Involved in Viral Replication and Gene Expression

    1. Front Matter

      Pages 46-46
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    2. RNA Higher-Order Structures Within the Coronavirus 5′ and 3′ Untranslated Regions and Their Roles in Viral Replication

      • Pinghua Liu, Julian Leibowitz
      Pages 47-61

    3. Programmed –1 Ribosomal Frameshifting in SARS Coronavirus

      • Jonathan D. Dinman
      Pages 63-72

  4. Viral Proteins

    1. Front Matter

      Pages 74-74
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    2. Expression and Functions of SARS Coronavirus Replicative Proteins

      • Rachel Ulferts, Isabelle Imbert, Bruno Canard, John Ziebuhr
      Pages 75-98

    3. SARS Coronavirus Replicative Enzymes: Structures and Mechanisms

      • Isabelle Imbert, Rachel Ulferts, John Ziebuhr, Bruno Canard
      Pages 99-114

    4. Quaternary Structure of the SARS Coronavirus Main Protease

      • Gu-Gang Chang
      Pages 115-128

    5. The Nucleocapsid Protein of the SARS Coronavirus: Structure, Function and Therapeutic Potential

      • Milan Surjit, Sunil K. Lal
      Pages 129-151

    6. SARS Coronavirus Accessory Gene Expression and Function

      • Scott R. Schaecher, Andrew Pekosz
      Pages 153-166

    7. SARS Accessory Proteins ORF3a and 9b and Their Functional Analysis

      • Wei Lu, Ke Xu, Bing Sun
      Pages 167-175

    8. Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab

      • Choong-Tat Keng, Yee-Joo Tan
      Pages 177-191

  5. Viral pathogenesis and host immune response

    1. Front Matter

      Pages 194-194
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    2. SARS Coronavirus Pathogenesis and Therapeutic Treatment Design

      • Timothy P. Sheahan, Ralph S. Baric
      Pages 195-230

    3. Modulation of Host Cell Death by SARS Coronavirus Proteins

      • Claudia Diemer, Martha Schneider, Hermann M. Schätzl, Sabine Gilch
      Pages 231-245

    4. SARS Coronavirus and Lung Fibrosis

      • Wei Zuo, Xingang Zhao, Ye-Guang Chen
      Pages 247-258
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Keywords

About this book

SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.

Reviews

From the reviews:

“This volume provides a useful portal for postgraduate students and researchers into selected aspects of SARSr-CoV molecular biology. … this volume would be most useful to postgraduate students entering the field of SARSr-CoV research.” (Stuart Siddell, The Quarterly Review of Biology, Vol. 87, March, 2012)

Editors and Affiliations

  • Engineering & Biotechnology, International Centre for Genetic, New Delhi, India

    Sunil K. Lal

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