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Breast Cancer Biology for the Radiation Oncologist

  • Book
  • © 2015

Overview

Editors:
  1. Jonathan Strauss

    1. Department of Radiation Oncology, Northwestern University, Chicago, USA

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  2. William Small

    1. Division of Radiation Oncology, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Chicago, USA

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  3. Gayle E. Woloschak

    1. Dept. Radiology, Northwestern University Feinberg School of Medicine, Chicago, USA

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  • First textbook to describe the biological complexities of breast cancer in a way that is relevant to the radiation oncologist
  • Covers a range of important emerging issues
  • Offers practical treatment recommendations based on available clinical evidence
  • Includes supplementary material: sn.pub/extras

Part of the book series: Medical Radiology (MEDRAD)

Part of the book sub series: Radiation Oncology (Med Radiol Radiat Oncol)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-vii
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  2. Biological Subtypes of Breast Cancer

    • Sara E. Barnato, William J. Gradishar
    Pages 1-6

  3. Gene Amplification of ErbB-2: From Gene to Therapy

    • Kinnari Pandya, Clodia Osipo
    Pages 7-13

  4. Current Clinical Role of Genetic Profiling in Breast Cancer

    • Ruta Rao, Mashrafi Ahmed, William T. Leslie
    Pages 15-34

  5. Biology of DCIS and Progression to Invasive Disease

    • Sanaz A. Jansen
    Pages 35-48

  6. Cancer Stem Cells and Radiotherapy

    • Jian Jian Li
    Pages 49-57

  7. Genetic Basis of Normal Tissue Radiosensitivity and Late Toxicity in Breast Cancer

    • Dhara MacDermed
    Pages 59-70

  8. Genetic Syndromes and Radiotherapy in Breast Cancer

    • Camille Green, Atif J. Khan, Bruce G. Haffty
    Pages 71-80

  9. Experimental Therapies in Breast Cancer

    • Bryan M. Rabatic
    Pages 81-90
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Keywords

About this book

This is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as different intrinsic sensitivity to radiotherapy. Multi-gene arrays that have for years been used to predict the risk of distant recurrence and the value of systemic chemotherapy may also have utility in predicting the risk of local recurrence. Additionally, the targeted agents used to treat breast cancer may interact with radiotherapy in ways that can be beneficial or undesirable.  All of these emerging issues are extensively discussed in this book, and practical evidence-based treatment recommendations are presented whenever possible.

Editors and Affiliations

  • Department of Radiation Oncology, Northwestern University, Chicago, USA

    Jonathan Strauss

  • Division of Radiation Oncology, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Chicago, USA

    William Small

  • Dept. Radiology, Northwestern University Feinberg School of Medicine, Chicago, USA

    Gayle E. Woloschak

Bibliographic Information

  • Book Title: Breast Cancer Biology for the Radiation Oncologist

  • Editors: Jonathan Strauss, William Small, Gayle E. Woloschak

  • Series Title: Medical Radiology

  • DOI: https://doi.org/10.1007/978-3-642-31220-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-642-31219-9Published: 02 June 2015

  • Softcover ISBN: 978-3-662-52074-1Published: 01 November 2016

  • eBook ISBN: 978-3-642-31220-5Published: 04 May 2015

  • Series ISSN: 0942-5373

  • Series E-ISSN: 2197-4187

  • Edition Number: 1

  • Number of Pages: VII, 90

  • Number of Illustrations: 10 b/w illustrations, 5 illustrations in colour

  • Topics: Radiotherapy, Oncology

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