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Phosphoinositide 3-kinase in Health and Disease

Volume 1

  • Book
  • © 2011

Overview

Editors:
  1. Christian Rommel

    1. Intellikine, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Bart Vanhaesebroeck

    1. , Institute of Cancer and the London Schoo, Queen Mary, University of London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  3. Peter K. Vogt

    1. , Dept. Molecular & Exp. Medicine, Scripps Research Institute, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  • PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone
  • The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many
  • However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 346)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    • Tina L. Yuan, Lewis C. Cantley
    Pages 1-7

  3. PDK1: The Major Transducer of PI 3-Kinase Actions

    • José Ramón Bayascas
    Pages 9-29

  4. Protein Kinase B (PKB/Akt), a Key Mediator of the PI3K Signaling Pathway

    • Elisabeth Fayard, Gongda Xue, Arnaud Parcellier, Lana Bozulic, Brian A. Hemmings
    Pages 31-56

  5. PI3Ks in Lymphocyte Signaling and Development

    • Klaus Okkenhaug, David A. Fruman
    Pages 57-85

  6. The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions

    • Jonathan M. Backer
    Pages 87-114

  7. Phosphoinositide Signalling Pathways in Metabolic Regulation

    • Lazaros C. Foukas, Dominic J. Withers
    Pages 115-141

  8. Role of RAS in the Regulation of PI 3-Kinase

    • Esther Castellano, Julian Downward
    Pages 143-169

  9. More Than Just Kinases: The Scaffolding Function of PI3K

    • Carlotta Costa, Emilio Hirsch
    Pages 171-181

  10. PI3K Signaling in Neutrophils

    • Phillip T. Hawkins, Len R. Stephens, Sabine Suire, Michael Wilson
    Pages 183-202

  11. PI 3-Kinase p110β Regulation of Platelet Integrin αIIbβ3

    • Shaun P. Jackson, Simone M. Schoenwaelder
    Pages 203-224

  12. Regulatory Subunits of Class IA PI3K

    • David A. Fruman
    Pages 225-244

  13. The Neurodevelopmental Implications of PI3K Signaling

    • Kathryn Waite, Britta J. Eickholt
    Pages 245-265

  14. PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy

    • David J. Glass
    Pages 267-278

  15. Taking PI3Kδ and PI3Kγ One Step Ahead: Dual Active PI3Kδ/γ Inhibitors for the Treatment of Immune-Mediated Inflammatory Diseases

    • Christian Rommel
    Pages 279-299

  16. Back Matter

    Pages 301-308
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Keywords

About this book

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here

Editors and Affiliations

  • Intellikine, La Jolla, USA

    Christian Rommel

  • , Institute of Cancer and the London Schoo, Queen Mary, University of London, London, United Kingdom

    Bart Vanhaesebroeck

  • , Dept. Molecular & Exp. Medicine, Scripps Research Institute, La Jolla, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: Phosphoinositide 3-kinase in Health and Disease

  • Book Subtitle: Volume 1

  • Editors: Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-13663-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2011

  • Hardcover ISBN: 978-3-642-13662-7Published: 01 October 2010

  • Softcover ISBN: 978-3-642-26522-8Published: 07 November 2012

  • eBook ISBN: 978-3-642-13663-4Published: 17 October 2010

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 310

  • Number of Illustrations: 6 b/w illustrations, 23 illustrations in colour

  • Topics: Cancer Research, Human Physiology, Molecular Medicine

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