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Sensory and Metabolic Control of Energy Balance

  • Book
  • © 2010

Overview

Editors:
  1. Wolfgang Meyerhof

    1. Potsdam-Rehbrücke (DIFE), Abt. Molekulare Genetik, Deutsches Institut für Ernährungsforschu, Nuthetal, Germany

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  2. Ulrike Beisiegel

    1. Hamburg, Germany

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  3. Hans-Georg Joost

    1. German Institute of Human Nutrition Pots, Nuthetal, Germany

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  • Up-to-date account of the scientific progress made in the understanding of molecular mechanisms regulating energy metabolism
  • Special emphasis on obesity
  • Written by experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 52)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Genetic Basis of Obesity and Type 2 Diabetes: Lessons from the New Zealand Obese Mouse, a Polygenic Model of the Metabolic Syndrome

    • Hans-Georg Joost
    Pages 1-11

  3. Regulation of Nutrient Metabolism and Inflammation

    • Sander Kersten
    Pages 13-25

  4. Lipid Storage in Large and Small Rat Adipocytes by Vesicle-Associated Glycosylphosphatidylinositol-Anchored Proteins

    • Günter Müller, Susanne Wied, Elisabeth-Ann Dearey, Eva-Maria Wetekam, Gabriele Biemer-Daub
    Pages 27-34

  5. Autophagy and Regulation of Lipid Metabolism

    • Rajat Singh
    Pages 35-46

  6. Gene Co-Expression Modules and Type 2 Diabetes

    • Alan D. Attie, Mark P. Keller
    Pages 47-56

  7. Role of Zinc Finger Transcription Factor Zfp69 in Body Fat Storage and Diabetes Susceptibility of Mice

    • Stephan Scherneck, Heike Vogel, Matthias Nestler, Reinhart Kluge, Annette Schürmann, Hans-Georg Joost
    Pages 57-68

  8. Metabolic Sensing in Brain Dopamine Systems

    • Ivan E. de Araujo, Xueying Ren, Jozélia G. Ferreira
    Pages 69-86

  9. Oral and Extraoral Bitter Taste Receptors

    • Maik Behrens, Wolfgang Meyerhof
    Pages 87-99

  10. Reciprocal Modulation of Sweet Taste by Leptin and Endocannabinoids

    • Mayu Niki, Masafumi Jyotaki, Ryusuke Yoshida, Yuzo Ninomiya
    Pages 101-114

  11. Roles of Hormones in Taste Signaling

    • Yu-Kyong Shin, Josephine M. Egan
    Pages 115-137

  12. Endocannabinoid Modulation in the Olfactory Epithelium

    • Esther Breunig, Dirk Czesnik, Fabiana Piscitelli, Vincenzo Di Marzo, Ivan Manzini, Detlev Schild
    Pages 139-145

  13. The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel

    • Kristal Tucker, Melissa Ann Cavallin, Patrick Jean-Baptiste, K. C. Biju, James Michael Overton, Paola Pedarzani et al.
    Pages 147-157

  14. Energy Homeostasis Regulation in Drosophila: A Lipocentric Perspective

    • Ronald P. Kühnlein
    Pages 159-173

  15. Towards Understanding Regulation of Energy Homeostasis by Ceramide Synthases

    • Reinhard Bauer
    Pages 175-181

  16. Role of the Gut Peptide Glucose-Induced Insulinomimetic Peptide in Energy Balance

    • Andreas F. H. Pfeiffer, Natalia Rudovich, Martin O. Weickert, Frank Isken
    Pages 183-188

  17. Adipocyte–Brain: Crosstalk

    • Carla Schulz, Kerstin Paulus, Hendrik Lehnert
    Pages 189-201

  18. Back Matter

    Pages 203-205
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Keywords

About this book

During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scienti?c insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfor- nately, therapeutic options to prevent or cure this disease are extremely limited, posing an extraordinary challenge for today’s biomedical research community. Obesity results from imbalanced energy metabolism leading to lipid storage. Only detailed understanding of the multiple molecular underpinnings of energy metabolism can provide the basis for future therapeutic options. Numerous aspects of obesity are currently studied, including the essential role of neural and endocrine control circuits, adaptive responses of catabolic and anabolic pathways, metabolic fuel sensors, regulation of appetite and satiation, sensory information processing, transcriptional control of metabolic processes, and the endocrine role of adipose tissue. These studies are predominantly fuelled by basic research on mammalian models or clinical studies, but these ?ndings were paralleled by important insights, which have emerged from studying invertebrate models.

Editors and Affiliations

  • Potsdam-Rehbrücke (DIFE), Abt. Molekulare Genetik, Deutsches Institut für Ernährungsforschu, Nuthetal, Germany

    Wolfgang Meyerhof

  • Hamburg, Germany

    Ulrike Beisiegel

  • German Institute of Human Nutrition Pots, Nuthetal, Germany

    Hans-Georg Joost

Bibliographic Information

  • Book Title: Sensory and Metabolic Control of Energy Balance

  • Editors: Wolfgang Meyerhof, Ulrike Beisiegel, Hans-Georg Joost

  • Series Title: Results and Problems in Cell Differentiation

  • DOI: https://doi.org/10.1007/978-3-642-14426-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Hardcover ISBN: 978-3-642-14425-7Published: 24 September 2010

  • Softcover ISBN: 978-3-642-26518-1Published: 06 November 2012

  • eBook ISBN: 978-3-642-14426-4Published: 24 September 2010

  • Series ISSN: 0080-1844

  • Series E-ISSN: 1861-0412

  • Edition Number: 1

  • Number of Pages: VIII, 208

  • Number of Illustrations: 12 b/w illustrations, 30 illustrations in colour

  • Topics: Cell Biology

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