Editors:
- Conceived for beginners
- Not only for medicinal chemists, but any biologist, chemist, mathematician or IT scientist interested in that field
- Written by experts from both the academic (University) and private (Pharma companies) sectors
- Shows more applications than just drug discovery
- Includes supplementary material: sn.pub/extras
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Table of contents (17 chapters)
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Front Matter
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Automated Pharmacological Screening
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Front Matter
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AUTOMATED PHARMACOLOGICAL SCREENING
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High-Content Screening and Strategies in Chemical Genetics
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Front Matter
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HIGH-CONTENT SCREENING AND THE STRATEGIES FOR CHEMICAL GENETICS
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Towards an in Silico Exploration of Chemical and Biological Spaces
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Front Matter
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TOWARDS AN IN-SILICO EXPLORATION OF CHEMICAL AND BIOLOGICAL SPACE
About this book
Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline.
This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.
Editors and Affiliations
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UMR 5168 CNRS CEA INRA UNIV JF, Joseph Fourier University, 38054 Grenoble Cedex 9, France
ERIC MARECHAL
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Institute of Life Sciences Research and, Lab. of Plant Cell Physiology, CNRS-CEA-INRA, Joseph Fourier University, Grenoble, France
Sylvaine Roy
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Department of Cellular Differentiation a, Albert Bonniot Institute, La Tronche Cedex, France
Laurence Lafanechère
Bibliographic Information
Book Title: Chemogenomics and Chemical Genetics
Book Subtitle: A User's Introduction for Biologists, Chemists and Informaticians
Editors: ERIC MARECHAL, Sylvaine Roy, Laurence Lafanechère
DOI: https://doi.org/10.1007/978-3-642-19615-7
Publisher: Springer Berlin, Heidelberg
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2011
Hardcover ISBN: 978-3-642-19614-0Published: 17 June 2011
Softcover ISBN: 978-3-662-51991-2Published: 23 August 2016
eBook ISBN: 978-3-642-19615-7Published: 21 June 2011
Edition Number: 1
Number of Pages: XI, 256
Additional Information: Original French edition published by EDP Sciences, 2007, Jointly published with Grenoble Sciences
Topics: Medicinal Chemistry, Computer Applications in Chemistry, Bioinformatics, Biotechnology, Agriculture