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Small-Molecule Inhibitors of Protein-Protein Interactions

  • Book
  • © 2011

Overview

Editors:
  1. Lyubomir Vassilev

    1. Roche Research Center, Dept. Discovery Oncology, Hoffmann-La Roche Inc., Nutley, USA

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  2. David Fry

    1. Roche Research Center, Dept. of Discovery Oncology, Hoffmann-La Roche Inc., Nutley, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions
  • The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies
  • There are various focal points, including methodologies and the molecules themselves
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 348)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-x
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  2. Hydrogen-Bonded Synthetic Mimics of Protein Secondary Structure as Disruptors of Protein-Protein Interactions

    • Marc J. Adler, Andrew G. Jamieson, Andrew D. Hamilton
    Pages 1-23

  3. Small-Molecule Inhibitors of IL-2/IL-2R: Lessons Learned and Applied

    • C. G. M. Wilson, M. R. Arkin
    Pages 25-59

  4. Small Molecule Inhibitors of the Human Papillomavirus E1-E2 Interaction

    • Peter W. White, Anne-Marie Faucher, Nathalie Goudreau
    Pages 61-88

  5. Design of Small-Molecule Smac Mimetics as IAP Antagonists

    • Shaomeng Wang
    Pages 89-113

  6. Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Proangiogenic Signaling Molecule

    • Benjamin D. Zeitlin, Jacques E. Nör
    Pages 115-137

  7. Small-Molecule Modulators of c-Myc/Max and Max/Max Interactions

    • Thorsten Berg
    Pages 139-149

  8. Small-Molecule Inhibitors of the p53-MDM2 Interaction

    • Binh T. Vu, Lyubomir Vassilev
    Pages 151-172

  9. Back Matter

    Pages 173-174
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Keywords

About this book

In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field

Editors and Affiliations

  • Roche Research Center, Dept. Discovery Oncology, Hoffmann-La Roche Inc., Nutley, USA

    Lyubomir Vassilev

  • Roche Research Center, Dept. of Discovery Oncology, Hoffmann-La Roche Inc., Nutley, USA

    David Fry

Bibliographic Information

  • Book Title: Small-Molecule Inhibitors of Protein-Protein Interactions

  • Editors: Lyubomir Vassilev, David Fry

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-17083-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2011

  • Hardcover ISBN: 978-3-642-17082-9Published: 12 January 2011

  • Softcover ISBN: 978-3-642-26670-6Published: 27 February 2013

  • eBook ISBN: 978-3-642-17083-6Published: 18 January 2011

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 174

  • Topics: Biomedicine general

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