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Aquaporins

  • Book
  • © 2009

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Editors:
  1. Eric Beitz

    1. Pharmazeutisches Inst., Universität Kiel, Kiel, Germany

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 190)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Aquaporin Protein Structure and Selectivity Mechanisms

    1. Discovery of the Aquaporins and Development of the Field

      • Jennifer M. Carbrey, Peter Agre
      Pages 3-28

    2. The AQP Structure and Functional Implications

      • Thomas Wspalz, Yoshinori Fujiyoshi, Andreas Engel
      Pages 31-56

    3. Dynamics and Energetics of Permeation Through Aquaporins. What Do We Learn from Molecular Dynamics Simulations?

      • Jochen S. Hub, Helmut Grubmüller, Bert L. de Groot
      Pages 57-76

    4. In Vitro Analysis and Modification of Aquaporin Pore Selectivity

      • Eric Beitz, Dana Becker, Julia von Bülow, Christina Conrad, Nadine Fricke, Amornrat Geadkaew et al.
      Pages 77-92

  3. Aquaporin Function in Mammalian Water Homeostasis

    1. Aquaporins in the Kidney

      • Tae-Hwan Kwon, Jakob Nielsen, Hanne B. Møller, Robert A. Fenton, Søren Nielsen, Jørgen Frøkiær
      Pages 95-132

    2. Regulation of Aquaporin-2 Trafficking

      • Pavel I. Nedvetsky, Grazia Tamma, Sven Beulshausen, Giovanna Valenti, Walter Rosenthal, Enno Klussmann
      Pages 133-157

    3. Role of Aquaporin-4 in Cerebral Edema and Stroke

      • Zsolt Zador, Shirley Stiver, Vincent Wang, Geoffrey T. Manley
      Pages 159-170

    4. Aquaporins as Potential Drug Targets for Meniere's Disease and its Related Diseases

      • Taizo Takeda, Daizo Taguchi
      Pages 171-184

    5. Aquaporins in Secretory Glands and their Role in Sjögren's Syndrome

      • Christine Delporte
      Pages 185-201

  4. Aquaporin Glycerol Permeability in Mammalian Physiology

    1. Skin Aquaporins: Function in Hydration, Wound Healing, and Skin Epidermis Homeostasis

      • Mathieu Boury-Jamot, Jean Daraspe, Frédéric Bonté, Eric Perrier, Sylvianne Schnebert, Marc Dumas et al.
      Pages 205-217

    2. Function of Aquaporin-7 in the Kidney and the Male Reproductive System

      • Eisei Sohara, Shinichi Uchida, Sei Sasaki
      Pages 219-231

    3. Role of Aquaporin-7 and Aquaporin-9 in Glycerol Metabolism; Involvement in Obesity

      • Norikazu Maeda, Toshiyuki Hibuse, Tohru Funahashi
      Pages 233-249

    4. New Members of Mammalian Aquaporins: AQP10–AQP12

      • Kenichi Ishibashi
      Pages 251-262

  5. Aquaporin Functions Apart from Water and Glycerol Transport

    1. Structural Function of MIP/Aquaporin 0 in the Eye Lens; Genetic Defects Lead to Congenital Inherited Cataracts

      • Ana B. Chepelinsky
      Pages 265-297

    2. pH Regulated Anion Permeability of Aquaporin-6

      • Masato Yasui
      Pages 299-308

    3. Aquaglyceroporins and Metalloid Transport: Implications in Human Diseases

      • Hiranmoy Bhattacharjee, Barry P. Rosen, Rita Mukhopadhyay
      Pages 309-325

    4. Ammonia and Urea Permeability of Mammalian Aquaporins

      • Thomas Litman, Rikke Søgaard, Thomas Zeuthen
      Pages 327-358

    5. Knock-Out Models Reveal New Aquaporin Functions

      • Alan S. Verkman
      Pages 359-381

  6. Towards Therapeutic Use of Aquaporins

    1. Design, Synthesis and Assaying of Potential Aquaporin Inhibitors

      • Rose Haddoub, Michael Rützler, Aélig Robin, Sabine L. Flitsch
      Pages 385-402
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Keywords

About this book

The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.

Editors and Affiliations

  • Pharmazeutisches Inst., Universität Kiel, Kiel, Germany

    Eric Beitz

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