Overview
- Editors:
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Ingolf Bernhardt
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Naturwissenschaftlich-Technische Fakultät III, Arbeitsgruppe Biophysik, Universität des Saarlandes, Saarbrücken, Germany
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J. Clive Ellory
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Laboratory of Physiology, University of Oxford, Oxford, UK
51 worldwide leading experts in the field of erythrocyte research contributed to the 31 chapters of this book, which is the first on transport processes in red blood cells.
Includes supplementary material: sn.pub/extras
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Table of contents (31 chapters)
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Front Matter
Pages I-XXVIII
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- Ingolf Bernhardt, Erwin Weiss
Pages 83-109
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- Poul Bennekou, Palle Christophersen
Pages 139-152
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- René Motais, Hélène Guizouarn, Franck Borgese
Pages 153-171
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- John S. Gibson, J. Clive Ellory
Pages 197-220
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- Sigrid Lepke, Joachim Heberle, Hermann Passow
Pages 221-252
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- Philip A. Knauf, Prithwish Pal
Pages 253-301
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- J. Clive Ellory, Pawel Swietach, John S. Gibson
Pages 303-319
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- James D. Young, Sylvia Y. M. Yao, Carol E. Cass, Stephen A. Baldwin
Pages 321-337
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- Teresa Tiffert, Robert M. Bookchin, Virgilio L. Lew
Pages 373-405
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- Niall M. Horn, Alan L. Thomas, Fiona Oakley
Pages 435-450
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- Joseph Browning, Robert Wilkins
Pages 477-488
About this book
The red cell has been a focus for scientific and medical investigation since the ear liest times. A higher erythrocyte sedimentation rate was associated with diseases (usually pyrexias) before the thermometer was invented. Furthermore, ever since the early observers Swammerdam and Leeuvenhoek saw discrete corpuscles in samples of blood using the first microscopes, there has been a significant scientific interest in the structure and function of red blood cells. The later discovery that red cells were not spherical, but biconcave discs introduced a scientific puzzle which is still not completely resolved today, and identified the need for a detailed knowledge of the plasma membrane composition and structure, and its interaction with the cytoskeleton. Important concepts like the lipid bilayer, together with its more recent refinement as asymmetric in phospholipid composition led to the identification of translocases involved in actively maintaining its composition. Understanding the mechanics of red cell deformation as these biconcave discs traverse capillaries was advanced by the pioneering work of Rand and Burton in the Sixties, and progressed by Evans, Skalak and others. Based on the bilayer couple hypothesis, the shape changes that are possible for a human red cell from echinocyte to stomatocyte were described by Sheetz and Singer in the Seventies in terms of alterations in the individual halves of the bilayer. Certain clinical condi tions are associated with obvious changes in red cell morphology.
Reviews
From the reviews:
"Membrane transport is a multi-faceted topic that can be looked at from various angles: biochemical, biophysical, cell biological. ‘Red Cell Membrane Transport in Health and Disease’ features contributions … from all of these areas, rendering a rather comprehensive treatise. … Bringing together chemically and physically oriented membrane researchers, the editors have assembled an impressive and varied body of knowledge that ought to be of interest in any laboratory involved in membrane transport research … ." (T. A. Lazar, Hämostaseologie, Issue 3, 2005)
Editors and Affiliations
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Naturwissenschaftlich-Technische Fakultät III, Arbeitsgruppe Biophysik, Universität des Saarlandes, Saarbrücken, Germany
Ingolf Bernhardt
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Laboratory of Physiology, University of Oxford, Oxford, UK
J. Clive Ellory
