Overview
- Editors:
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Uwe R. Müller
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V.P., Applied Science Nanosphere, Inc., Northbrook, USA
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Dan V. Nicolau
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Swinburne University of Technology, Hawthorn, Australia
- First comprehensive book on microarrays, a topic that is becoming enormously important in genetics, biochemistry and medicine
- Includes supplementary material: sn.pub/extras
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Table of contents (20 chapters)
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Front Matter
Pages I-XXII
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General Microarray Technologies
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- Ralph R. Martel, Matthew P. Rounseville, Ihab W. Botros, Bruce E. Seligmann
Pages 3-22
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- Kristi L. Hanson, Luisa Filipponi, Dan V. Nicolau
Pages 23-44
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- Alvaro Carrillo, Kunal V. Gujraty, Ravi S. Kane
Pages 45-61
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- Uwe R. Müller, Roeland Papen
Pages 73-88
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- Dan V. Nicolau, Linnette Demers, David S. Ginger
Pages 89-118
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- Piotr Grodzinski, Robin H. Liu, Ralf Lenigk, Yingjie Liu
Pages 119-145
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- James J. Storhoff, Sudhakar S. Marla, Viswanadham Garimella, Chad A. Mirkin
Pages 147-179
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- Matthias Vaupel, Andreas Eing, Karl-Otto Greulich, Jan Roegener, Peter Schellenberg, Hans Martin. Striebel et al.
Pages 181-207
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DNA Microarrays
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- Ulrika Liljedahl, Mona Fredriksson, Ann-Christine Syvänen
Pages 211-227
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- Ramesh Ramakrishnan, Paul Bao, Uwe R. Müller
Pages 229-250
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- Carsten Schwaenena, Michelle Nesslinga, Bernhard Radlwimmera, Swen Wessendorf, Peter Lichtera
Pages 251-263
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Protein Microarrays
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- Hendrik Weiner, Jörn Glökler, Claus Hultschig, Konrad Büssow, Gerald Walter
Pages 279-295
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- Ye Fang, Anthony G. Frutos, Yulong Hong, Joydeep Lahiri
Pages 309-320
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Cell & Tissue Microarrays
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- Ronald Simon, Martina Mirlacher, Guido Sauter
Pages 345-360
About this book
Ithasbeenstatedthatourknowledgedoublesevery20years,butthatmaybe an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA isthegeneticmaterialtoabasicmolecularunderstandingofourselvesandthe living world around us in less than 50 years. Crucial to this rapid progress was thediscoveryofthedouble-helicalstructureofDNA,whichlaidthefoundation forallhybridizationbasedtechnologies. Thediscoveriesofrestrictionenzymes, ligases, polymerases, combined with key innovations in DNA synthesis and sequencing ushered in the era of biotechnologyas a new science with profound sociological and economic implications that are likely to have a dominating in?uence on the development of our society during this century. Given the process by which science builds on prior knowledge, it is perhaps unfair to single out a few inventions and credit them with having contributed most to thisavalancheofknowledge. Yet,therearesurelysomethatwillberecognized as having had a more profound impact than others, not just in the furthering of our scienti?c knowledge, but by leveraging commercial applications that provide a tangible return to our society. The now famous Polymerase Chain Reaction, or PCR, is surely one of those, as it has uniquely catalyzed molecular biology during the past 20 years, and continues to have a signi?cant impact on all areas that involve nucleic acids, ranging from molecular pathology to forensics. Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.
Editors and Affiliations
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V.P., Applied Science Nanosphere, Inc., Northbrook, USA
Uwe R. Müller
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Swinburne University of Technology, Hawthorn, Australia
Dan V. Nicolau
