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IGFs in the Nervous System

  • Book
  • © 1998

Overview

Editors:
  1. Eugenio E. Müller

    1. Department of Medical Pharmacology, University of Milan, Milan, Italy

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-XI
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  2. New Experimental Models for the Study of IGF and IGF-Binding Protein Action in the Brain

    • M. Holzenberger, E. Gay, S. Doublier, M. Binoux
    Pages 1-16

  3. The Insulin-like Growth Factor-I Receptor and the Central Nervous System: Mechanisms Involved in the Prevention of Apoptosis

    • D. Le Roith, M. Párrizas, V. A. Blakesley
    Pages 17-27

  4. IGF-I in Neuronal Differentiation and Neuroprotection

    • K. A. Sullivan, B. Kim, J. W. Russell, E. L. Feldman
    Pages 28-46

  5. Insulin-like Growth Factor I: Regulation and Interactions During Aging-Induced Cognitive Decline and Impairment Within the Hippocampus

    • P. K. Lund, K. L. Stenvers, M. Gallagher
    Pages 47-59

  6. The Role of IGF-I in Cerebellar Granule Cell Survival and Terminal Differentiation

    • P. Calissano, M. T. Ciotti, C. Galli, D. Mercanti, L. Dus, N. Canu et al.
    Pages 60-71

  7. Regulation of Oligodendrocyte Development and CNS Myelination by IGF-I: Prospects for Disease Therapy

    • F. A. Mcmorris, G. S. Vemuri, É. Boyle-Walsh, R. Mewar, M. J. Engleka, G. Lesh
    Pages 72-83

  8. IGF-I and Glycosaminoglycans Improve Peripheral Nerve Regeneration and Motor Neuron Survival in Models of Motor Neuron Disease

    • A. Gorio, L. Vergani, M. Losa, G. Pezzoni, L. Calvano, C. Finco et al.
    Pages 84-95

  9. The Potential of IGF-I as a Neuronal Rescue Agent

    • P. D. Gluckman, C. E. Williams, J. Guan, A. Scheepens, R. Zhang, V. Russo et al.
    Pages 96-104

  10. Neurobiology of rhIGF-I: Rationale for Use in Motor Neuron Disease

    • J. L. Vaught, P. C. Contreras, M. Miller, N. Neff
    Pages 105-114

  11. rhIGF-I for the Treatment of Neuromuscular Disorders

    • V. Silani, A. Brioschi, A. Sampietro, A. Ciammola, A. Pizzuti, G. Scarlato
    Pages 115-126

  12. Insulin-like Growth Factor-I Effects on ADP-Ribosylation Processes and Interactions with Glucocorticoids During Maturation and Differentiation of Astroglial Cells in Primary Culture

    • R. Avola, V. Spina Purrello, A. Costa, S. Reale, N. Marletta, N. Ragusa et al.
    Pages 127-134

  13. Anti-Insulin-like Growth Factor I Antibodies Affect Locomotion and Passive Avoidance Performances in Sprague-Dawley Rats

    • D. Santucci, M. Luoni, A. Torsello, I. Branchi, E. E. Mùller, E. Alleva
    Pages 135-144

  14. Neuroprotective Effect of GPE Pretreatment on Rat Hippocampal Organotypic Cultures Exposed to NMDA

    • L. Curatolo, G. L. Raimondi, C. Caccia, E. Wong, S. Gatti, C. Post
    Pages 145-150

  15. Expression of IGF-I and IGF-I Receptor mRNA in Sural Nerves of Diabetic Patients

    • M. Grandis, L. Nobbio, G. L. Mancardi, M. Abbruzzese, E. Maritato, L. Banchi et al.
    Pages 151-156

  16. Back Matter

    Pages 157-159
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Keywords

About this book

In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated.

Editors and Affiliations

  • Department of Medical Pharmacology, University of Milan, Milan, Italy

    Eugenio E. Müller

Bibliographic Information

  • Book Title: IGFs in the Nervous System

  • Editors: Eugenio E. Müller

  • DOI: https://doi.org/10.1007/978-88-470-2246-1

  • Publisher: Springer Milano

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Italia, Milano 1998

  • Softcover ISBN: 978-3-540-75042-0Published: 01 August 1997

  • eBook ISBN: 978-88-470-2246-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 159

  • Number of Illustrations: 123 b/w illustrations

  • Topics: Neurology, Endocrinology

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