Shock, Sepsis, and Organ Failure

1. Front Matter

   Pages I-X

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2. Cytokine Cascades in Sepsis

   1. Front Matter

      Pages 1-1

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   2. Tumor Necrosis Factor as a Mediator of Sepsis

      • Stephen F. Lowry, Kimberly J. VanZee, Craig S. Rock, William A. Thompson, Hester S. A. Oldenburg, Michael A. Rogy et al.

      Pages 3-17

   3. A Role for Interleukin-1 in Septic Shock

      • L. L. Moldawer, E. Fischer, K. Van Zee, W. A. Thompson, S. F. Lowry

      Pages 18-33

   4. Interleukin 6 as a Mediator of the Systemic Inflammatory Response

      • Stephen J. Migliori, Frank B. Cerra

      Pages 34-56

   5. E-Selectin, Internalization and Release

      • W. A. Buurman, E. J. U. von Asmuth, J. F. M. Leeuwenberg

      Pages 57-70

3. Cytokines in Hemorrhage, Trauma, and Inflammation

   1. Front Matter

      Pages 71-71

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   2. Alterations in Inflammatory Cytokine Production Following Hemorrhage and Resuscitation

      • Irshad H. Chaudry, Wolfgang Ertel, Alfred Ayala

      Pages 73-127

   3. Trauma and Cytokines

      • G. Schlag, H. Redl, S. Bahrami, J. Davies, P. Smuts, I. Marzi

      Pages 128-162

   4. Quantifying the Severity of the Human Response to Injury and Sepsis as a Guide to the Interpretation of Phatophysiologic Cytokine Effects

      • John H. Siegel, Shirin Godzari, William P. Coleman, Diana Malcolm, Stevin Blevins, David Frankenfield et al.

      Pages 163-204

   5. The Role of Cytokine Networks Mediating Inflammation and Ischemia-Reperfusion Injury

      • Robert M. Strieter, Lisa M. Colletti, Andrew P. Metinko, Mark W. Rolfe, Steven R. DeMeester, Theodore J. Standiford et al.

      Pages 205-230

   6. The Role of Cytokines and Adhesion Molecules in Lung Inflammation

      • Peter A. Ward, Michael S. Mulligan

      Pages 231-244

   7. Cytokine Response to Thermal Injury

      • Christopher W. Lentz, Stephen T. Zeigler, Charles S. Cox Jr., Lillian D. Traber, David N. Herndon, Daniel L. Traber

      Pages 245-269

4. Cytokines in Gram-Negative Bacteremia

   1. Front Matter

      Pages 271-271

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   2. Mechanism and Therapy of Gram-positive Bacteremia (Sepsis) in the Nonhuman Primate: Role of Cytokines

      • Lerner B. Hinshaw

      Pages 273-292

   3. Cytokines in Gram-Positive Bacteremia

      • Roger C. Bone

      Pages 293-304

5. Cytokines as Therapeutic Measures

   1. Front Matter

      Pages 305-305

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   2. Tumor Necrosis Factor-α and Interleukin-1 Desensitization: Clinical Utility and Possible Mechanisms

      • Jeffrey A. Norton, H. Richard Alexander

      Pages 307-331

   3. Interleukin-1 and its Receptor Antagonist as Candidate Therapeutic Agents for Severe Infections

      • Jos W. M. van der Meer, Maité Vogels, Jo H. A. J. Curfs, Bart-Jan Kuliberg, Wynand M. C. Eling

      Pages 332-342

6. Cytokines in Gram-Positive Bacteremia

   1. Front Matter

      Pages 343-343

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This book is the result of the 3rd Wiggers Bernard Conference. The Wiggers Bernard Conferences, named after two great physiologists of the past, are biannual gatherings of the leaders in the field of shock. The meetings focus on specific areas of interest, where a lot of new informations is available, but needs to be focused. There are informal presentations during which the seminarian can be intenupted in order to clarify a pat1icular point; formal discussions follow each presentation; these are followed by infOlmal gatherings in which these discussion continue in a very relaxed environment. The 1992 meeting took place in Obermayerhofen, a small but charming castle in the soft green hills of Eastern Styria in the South-Eastern part of Austria. The castle was built in 1130, restored and turned into a hotel in 1977. The renaissance court yard and the generous and exclusive decors make it one of the most beautiful castles in Austria. The frank beauty and hospitality of this area acted as a catalyst to crystalize the thoughts of this interdisciplinary group of scientists as they discussed new findings in the cytokine area.

• Multiorganversagen
• Organ Failure
• Schock
• Sepsis
• Shock
• Trauma
• infections

• Ludwig-Boltzmann-Institute for Experimental and Clinical Traumatology, Vienna, Austria

  Günther Schlag, Heinz Redl

• Department of Anesthesia, University of Texas, Galveston, USA

  Daniel Traber

Policies and ethics