Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances

1. Front Matter

   Pages I-XIII

   PDF

2. Young Scientists Award Lecture 1988

   1. Front Matter

      Pages 1-1

      PDF

   2. m-Dinitrobenzene: Studies on its Toxicity to the Testicular Sertoli Cell

      • P. M. D. Foster

      Pages 3-17

3. Mechanism of Metal Carcinogenicity

   1. Front Matter

      Pages 19-19

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   2. Metals — Epidemiological and Experimental Evidence for Carcinogenicity

      • R. R. Lauwerys

      Pages 21-27

   3. Mechanistic Aspects of Chromium Carcinogenicity

      • S. De Flora, D. Serra, C. Basso, P. Zanacchi

      Pages 28-39

   4. Mechanistic Aspects of Nickel Carcinogenicity

      • F. W. Sunderman Jr.

      Pages 40-47

   5. Differing Effects of Chromium(III) and Chromium(VI) on Nucleotides and DNA

      • Th. Wolf, R. Kasemann, H. Ottenwälder

      Pages 48-51

4. Individual Biomonitoring of Chemical Exposure

   1. Front Matter

      Pages 53-53

      PDF

   2. Nucleic Acid-Carcinogen Adducts in Human Dosimetry

      • D. E. G. Shuker

      Pages 55-65

   3. Molecular Dosimetry of Genotoxic Damage

      • R. A. Baan, A. M. J. Fichtinger-Schepman, L. Roza, G. P. van der Schans

      Pages 66-82

   4. Protein-Carcinogen Adducts in Human Dosimetry

      • P. B. Farmer, E. Bailey

      Pages 83-90

   5. Individual Exposure Monitoring from Plasma or Urinary Metabolite Determination

      • N. J. van Sittert

      Pages 91-100

   6. 32P-Postlabelling of DNA Adducts in White Blood Cells of Foundry Workers

      • K. Savela, S. Leppälä, K. Hemminki

      Pages 101-103

   7. A Sensitive Method for the Determination of Urinary Mercapturic Acids for use in Biological Monitoring

      • G. Kress, R. Pentz

      Pages 104-107

   8. Biological Monitoring of Exposure to Ethylene Glycol Ethers

      • G. Johanson, I. Michel, D. Norbäck, G. Nise, A. Tillberg

      Pages 108-111

   9. Liver Damage after Coal-tar Treatment does not Prevent Induction of Glutathione S-Transferases in Rat Liver

      • C. T. A. Evelo, J. Atema, J. H. J. Copius-Peereboom, P. H. S. Fijneman, J. C. L. M. Pertijs, R. P. Bos

      Pages 112-116

   10. The Significance of Urinary Thioethers as Indicators of Exposure to Alkylating Agents

       • A. E. Karakaya, S. Burgaz, A. Bayhan

       Pages 117-119

   11. Ethylenethiourea as an Indicator of Exposure to Ethylenebisdithiocarbamate Fungicides

       • K. Savolainen, P. Kurttio, T. Vartiainen, J. Kangas

       Pages 120-123

   12. Application of Flame Atom Trapping and Column Preconcentration Techniques to the Measurement of Cadmium in Urine

       • A. Karakaya, A. Taylor

       Pages 124-127

This supplement contains the papers submitted at EUROTOX 88, the joint Congress of the European Society of Toxicology and the Federation of the European Societies of Toxicology. The theme was one of monitoring and examining the effects of toxic substances in the biological response at the subcellular level. Mechanisms of metal carcinogenicity are discussed as well as the biomonitoring of chemical exposure. Reports are provided on the role of individual differences in man and the effect of risk assessment. Papers appear dealing with the genetic control of drug metabolizing enzymes. The role of metabolism in organic specific toxicity is discussed. Information is included on the toxicological impact of chemicals interfering with the endocrine system as well as on the effects of toxicants on the immune system. Presentations deal with the current status of risk assessment in environmental toxicology.

• biomonitoring
• biphenyls
• drug
• environment
• fungicide
• mercury
• metabolism
• nickel
• pesticide
• pharmacokinetics
• polychlorinated biphenyls
• toxicity
• toxicology
• xenobiotic
• xenobiotics

• Department of Pharmacology and Therapeutics, University of Dublin, Trinity College, Dublin 2, Ireland

  Philip L. Chambers, Claire M. Chambers

• Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg, West Germany

  Helmut Greim

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