Editors:
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 158)
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Table of contents (23 chapters)
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Front Matter
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General
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Front Matter
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Macrophage Targets in Inflammation
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Front Matter
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About this book
During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents.
The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.
Editors and Affiliations
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Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
Siamon Gordon
Bibliographic Information
Book Title: The Macrophage as Therapeutic Target
Editors: Siamon Gordon
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-642-55742-2
Publisher: Springer Berlin, Heidelberg
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eBook Packages: Springer Book Archive
Copyright Information: Springer-Verlag Berlin Heidelberg 2003
Hardcover ISBN: 978-3-540-44250-9Published: 10 July 2003
Softcover ISBN: 978-3-642-62919-8Published: 23 October 2012
eBook ISBN: 978-3-642-55742-2Published: 06 December 2012
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: X, 496
Topics: Immunology, Pharmacology/Toxicology, Virology