Coronary Circulation and Myocardial Ischemia

1. Front Matter

   Pages I-X

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2. Basic Physiology

   1. Front Matter

      Pages 1-1

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   2. Local Control of Coronary Blood Flow and Adenosine

      • F. S. Villanueva

      Pages 3-10

   3. Basic Mechanisms of Atherosclerosis: From Inflammation to Infection

      • L. Capron, B. Wyplosz

      Pages 11-19

3. Applied Physiology

   1. Front Matter

      Pages 21-21

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   2. Myocardial Ischemic Preconditioning

      • D. M. Van Winkle

      Pages 23-35

   3. Coronary Circulation in Sepsis

      • J.-F. Dhainaut, N. Marin, J. D. Chiche

      Pages 36-45

   4. Role of Inflammatory Response and Thrombosis in Acute Coronary Syndromes

      • A. Fernández Ortiz

      Pages 46-61

   5. Basic Aspects of Fibrinolysis and Thrombolysis

      • H. R. Lijnen, D. Collen

      Pages 62-71

4. Functional Assessment of the Coronary Circulation

   1. Front Matter

      Pages 73-73

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   2. Quantitative Echocardiographic Evaluation of Cardiac Function

      • J. Gorcsan III

      Pages 75-89

   3. Prognosis in Unstable Angina

      • J. Figueras

      Pages 90-98

   4. Assessment of Myocardial Viability

      • A. Flotats, I. Carrió

      Pages 99-113

   5. Functional Assessment of the Coronary Physiology: The Role of Magnetic Resonance

      • J. F. Toussaint

      Pages 114-124

5. Therapeutic and Clinical Applications

   1. Front Matter

      Pages 125-125

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   2. Intracoronary Ultrasound Imaging

      • J.-C. Tardif, J. Grégoire

      Pages 127-140

   3. Non-Antithrombotic Treatment of Acute Coronary Syndromes: Role of Beta-Blockers, Calcium Channel Blockers, and Nitrates

      • X. Bosch

      Pages 141-155

   4. Coronary Circulation and Myocardial Ischaemia: Thrombolysis

      • P. Sleight

      Pages 156-162

   5. Interventional Cardiology in the Treatment of Coronary Disease

      • C. Spaulding, R. Cador, S. Weber

      Pages 163-177

   6. Enhancement of Coronary Blood Flow as Myocardial Salvage Therapy

      • D. Karila-Cohen

      Pages 178-190

The coronary circulation is central to sustaining myocardial viability. Unlike the cir­ culations of most other organs, if the coronary circulation becomes insufficient to sustain myocardial contractile function, overall quality of life rapidly declines and life can abruptly end. In partnership with the cerebral circulation, the coronary circula­ tion plays a central role in sustaining life. However, unlike the cerebral circulation, whose function is self-sufficient to define life, the coronary circulation determines global blood flow and thus the initial state for the remainder of the body. This unique condition, together with the reality that coronary artery disease primarily affects peo­ ple in their productive years of life, has allowed physicians and scientists who study the heart to enjoy a privileged position in the field of medical research and clinical practice. Thus, it comes as little surprise that many new and exciting research developments involving the coronary circulation have recently come to the forefront of medical thinking. This reality, coupled with the large number of clinical trials of agents specif­ ically designed to sustain or improve coronary flow in many disease states, makes the timing of this monograph relevant. The book features papers presented at a recent international symposium, the fourth in a series of meetings on Applied Physiology of the Peripheral Circulation. The papers selected by the editors review the most impor­ tant advances in the fields of cardiology and the coronary circulation.

• Sepsis
• Tossie oxygenation
• angiography
• atherosclerosis
• blood substitutes
• cardiac function
• cardiology
• circulation
• dysoxia
• hemoglobin
• microcirculation
• physiology
• therapeutics
• ultrasound

• University of Pittsburgh School of Medicine, Pittsburgh, USA

  Michael R. Pinsky

• Department of Cell Biology and Physiology, Autonomous University, Barcelona, Spain

  Antonio Artigas

• Paris, France

  Jean-Francois Dhainaut

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