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Maturation Phenomenon in Cerebral Ischemia V

Fifth International Workshop April 28–May 1, 2002 Banff, Alberta, Canada

  • Conference proceedings
  • © 2004

Overview

Editors:
  1. Alastair M. Buchan

    1. Office of Stroke Research, Foothills Medical Centre, Calgary, Canada

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  2. Umeo Ito

    1. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

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  3. Fred Colbourne

    1. Department of Psychology, University of Alberta, Edmonton, Canada

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  4. Toshihiko Kuroiwa

    1. Department of Neuropathology Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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  5. Igor Klatzo

    1. Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, National Institutes of Health, Bethesda, USA

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Table of contents (46 papers)

  1. Front Matter

    Pages I-XX
    Download chapter PDF

  2. Role of Genetic Expression and Neuronal Apoptosis and/or Necrosis

    1. Front Matter

      Pages 1-1
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    2. Modulation of Neuronal Death by the Transcription Factor E2F1 in Experimental Stroke

      • J. P. MacManus, M. Jian, E. Preston, J. Webster, B. Zurakowski
      Pages 3-12

    3. Brain Genomic Responses to Ischemic Stroke, Hemorrhage, Seizures, Hypoglycemia and Hypoxia

      • Y. Tang, A. Lu, B. J. Aronow, K. R. Wagner, F. R. Sharp
      Pages 13-36

    4. Temporal Profile of Gene Induction After Venous Ischemia and Effects of Spreading Depression

      • T. Kaido, Y. Kamada, A. Heimann, T. Nishioka, O. Kempski, D. Bartsch et al.
      Pages 37-41

    5. The Role of Protein Phosphatases Type 2 C in Neuronal Apoptosis

      • Josef Krieglstein, Dagmar Selke, Yuan Zhu, Susanne Klumpp
      Pages 43-51

    6. Mitochondrial Cytochrome C- and Smac-Dependent Apoptosis in Cerebral Ischemia: Role of Oxidative Signaling

      • T. Sugawara, M. Ferrand-Drake, F. Yu, C. Maier, E. E. Hoyte, P. H. Chan
      Pages 53-61

    7. Erythropoietin: A Beneficial Approach to Neuroprotection in Stroke

      • H. Ehrenreich, A. L. Sirén
      Pages 63-64

    8. Transgenic Mutants for the Investigation of Molecular Stroke Mechanisms

      • K.-A. Hossmann, R. Hata, K. Maeda, T. Trapp, G. Mies
      Pages 65-77

  3. Ischemic Infarction: Inflammation

    1. Front Matter

      Pages 79-79
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    2. Compartmentalization in Focal Cerebral Ischemia

      • Gregory J. del Zoppo
      Pages 81-93

    3. Modulation of the Post-Ischemic Immune Response Improves Outcome in Focal Cerebral Ischemia: A Role for Lymphocytes in Stroke?

      • Kyra J. Becker, Darin L. Kindrick, John M. Hallenbeck, Richard M. McCarron, Robert K. Winn
      Pages 95-104

    4. Tumor Necrosis Factor-Alpha (TNF-a) and Ceramide Induce Tolerance to Ischemic and Hypoxic Insults to Brain and Brain Cells Associated with Changes in NFкB Function

      • I. Ginis, J. Hallenbeck
      Pages 105-111

    5. Microglial Proliferation and Cell Cycle Protein Upregulation in the Rat Hippocampus Following Forebrain Ischemia

      • H. Kato, A. Takahashi, Y. Itoyama
      Pages 113-119

    6. A Role for Cerebrovascular Endothelium in Ischemia and Reperfusion

      • M. Spatz, Y. Chen, Suzanne Golech, Alois Strasser, Joilet Bembry, A. Frederick et al.
      Pages 121-132

    7. Neural Stem Cells: Developmental Lessons May Yield Therapeutic Insights

      • Evan Y. Snyder
      Pages 133-133

  4. Clinical Trials/Neuroprotection

    1. Front Matter

      Pages 135-135
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    2. Experimental Neuroprotection: Translation to Human Stroke Trials

      • P. A. Barber, B. Bruederlin, A. M. Buchan
      Pages 137-156

  5. Factors and Mechanisms Enhancing Susceptibility or Tolerance (Glia)

    1. Front Matter

      Pages 157-157
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    2. Acid-Sensitive Ion Channels in Brain: New Modulation of Ischemic Injury

      • R. P. Simon
      Pages 159-165
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Keywords

About this book

The Maturation Phenomenon, first described by Ito et al. in 1975, refers to post­ ischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CAl pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evi­ dent that ischemic damage is not a sudden event but a process potentially suscep­ tible to therapeutic intervention. In September 1990, Ito and collaborators organized the First International Sym­ posium on "Maturation Phenomenon in Cerebral Ischemia" which was held in To­ kyo, Japan. The Second Symposium was organized in Tokyo, Japan in March/April 1996. The Third Symposium was held in Pozzilli, Italy in April 1998 and the Fourth Symposium was held in New Orleans, Louisiana, USA in October/Novem­ ber 1999. This book contains the presentations of the Fifth International Workshop on Maturation Phenomenon in Cerebral Ischemia held at the Rimrock Resort Ho­ tel in Banff, Alberta, Canada on April 28-May 1, 2002. It outlines the present sta­ tus of investigations and provides further stimulation for research in this field. The Maturation Phenomenon represents a continuing struggle for survival be­ tween the acceleration of tissue or neuronal death and the activation of defense mechanisms leading to neuronal recovery. The elucidation of these mechanisms is important for developing the ability to manipulate them during a long-lasting "therapeutic window".

Editors and Affiliations

  • Office of Stroke Research, Foothills Medical Centre, Calgary, Canada

    Alastair M. Buchan

  • Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    Umeo Ito

  • Department of Psychology, University of Alberta, Edmonton, Canada

    Fred Colbourne

  • Department of Neuropathology Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa

  • Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, National Institutes of Health, Bethesda, USA

    Igor Klatzo

Bibliographic Information

  • Book Title: Maturation Phenomenon in Cerebral Ischemia V

  • Book Subtitle: Fifth International Workshop April 28–May 1, 2002 Banff, Alberta, Canada

  • Editors: Alastair M. Buchan, Umeo Ito, Fred Colbourne, Toshihiko Kuroiwa, Igor Klatzo

  • DOI: https://doi.org/10.1007/978-3-642-18713-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2004

  • Softcover ISBN: 978-3-540-40874-1Published: 08 December 2003

  • eBook ISBN: 978-3-642-18713-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XX, 362

  • Topics: Neurology, Anesthesiology, Emergency Medicine, Neurosurgery

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