Biomedical and Life Physics

1. Front Matter

   Pages I-XVI

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2. Metabolic Control, Gowth, and Optimization

   1. Introduction to Session Metabolic Regulatory Systems

      • R. Heinrich

      Pages 1-5

   2. Metabolic Control Analysis Using Transient State Data

      • J. C. Liao, J. Delgado

      Pages 7-23

   3. Control of Dynamics and Steady State: Applications to Multidrug Resistance

      • H. V. Westerhoff, M. Bier, D. Molenaar, E. C. Spoelstra, J. Lankelma, A. P. M. Jongsma et al.

      Pages 25-31

   4. Parameter Space Classification of Solutions to a Mathematical Model for the Cortisol Secretion System in Normal Man

      • Y. Lenbury

      Pages 33-48

   5. Optimization of Glycogen Design in the Evolution of Metabolism

      • E. Meléndez-Hevia, T. G. Waddell, J. Sicilia

      Pages 49-59

   6. Tumor Growth and Treatment Planning: A Novel Simulation Approach

      • W. Düchting, T. Ginsberg, W. Ulmer

      Pages 61-69

   7. Maximization of Enzymic Activity under Consideration of Various Constraints

      • E. Klipp

      Pages 71-84

   8. Metabolic Control Theory

      • R. Heinrich

      Pages 85-99

   9. Determining Elementary Modes of Functioning in Biochemical Reaction Networks at Steady State

      • S. Schuster, C. Hilgetag, R. Schuster

      Pages 101-114

   10. On Inferring the Kinetic Scheme of an Ion Channel from Postsynaptic Currents

       • M. Bier, G. Borst, K. Kits

       Pages 115-124

   11. Mathematical Modelling of Red Blood Cell Enzyme Deficiencies as an Example for Large-Scale Parameter Changes in Biochemical Reaction Systems

       • R. Schuster, H.-G. Holzhütter

       Pages 125-135

   12. Simulation of Dioxygen Free Radical Reactions: Their Importance in the Initiation of Lipid Peroxidation

       • P. Moniz-Barreto, D. A. Fell

       Pages 137-144

   13. Residual Sodium and Potassium Fluxes Through Red Blood Cell Membranes

       • I. Bernhardt, S. Richter, K. Denner, R. Heinrich

       Pages 145-154

3. Electrocardiography: Processes and Analyses

   1. The Role of Natural Selection and Evolution in the Game of the Pentose Phosphate Cycle

      • F. Montero, J. C. Nuño, M. A. Andrade, C. Pérez-Iratxeta, F. Morán, E. Meléndez-Hevia

      Pages 155-168

   2. The Forward and Inverse Problems of Electrocardiography

      • B. M. Horáček

      Pages 169-172

   3. Simulation of the Spread of Excitation in the Myocardial Tissue

      • P. Colli Franzone, L. Guerri, M. Pennacchio

      Pages 173-180

   4. A Hybrid Model of Propagated Excitation in the Ventricular Myocardium

      • B. M. Horáček, J. Nenonen, J. A. Edens, L. J. Leon

      Pages 181-190

   5. Extracardiac Field due to Propagated Excitation in the Ventricular Myocardium

      • J. Nenonen, B. M. Horáček

      Pages 191-201

   6. Spatio-Temporal Constraints in Inverse Electrocardiography

      • A. van Oosterom, G. Huiskamp

      Pages 203-214

D. N. Ghista (Based on the Opening Address at the International Conference on Biomedical Physics & Mathematics of the Gauss Symposium, August 2, 1993 at Ludwig Maximillians Universitiit, Munchen, Germany) The traditional practice of Biomedical physics has now expanded to involve multiple aspects of medical practice: development of systems and technology in medical monitoring (e. g. , PET visualization of brain receptors to identify neuronal dysfunction), diagnosis (e. g. , computer-aided echocardiographic texture analysis to detect myocardial infarcts), organ­ support (e. g. , peritoneal dialysis), and therapeutic function (e. g. , encapsulation of insulin-producing pancreatic islet cells for treatment of diabetes). However, is Biomedical Physics a relatively new field? Not really, although we may have opened up new vistas of it, as presented in this book. Let us recall some early and well-known physician-cum-biomedical physicists. Both physical and physiological scientists will know of Jean Poiseuille (1799-1869), physician and physiologist; he measured blood pressure with a mercury manometer while being a medical student in Paris, received his medical degree in 1928, and then went on to describe the law of viscous flow (applicable to arteriolar flow).

• Bolus
• Synapse
• blood cell
• classification
• delivery
• drug delivery
• dynamics
• enzymes
• growth
• medicine
• metabolism
• modeling
• optimization
• temperature
• tissue

• Dept. of Bio Medical Engineering, University College of Engineering, Osmania University, Hyderabad, India

  Dhanjoo N. Ghista

Dr. Dhanjoo N. Ghista ist Professor am Department of Medical Physics & Engineering der United Arab Emirates University in Al Ain.

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