Stem Cell Drugs - A New Generation of Biopharmaceuticals

1. Front Matter

   Pages i-x

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2. Microvesicles

   1. Front Matter

      Pages 1-1

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   2. Using Stem Cell-Derived Microvesicles in Regenerative Medicine: A New Paradigm for Cell-Based-Cell-Free Therapy

      • Mohammad Amin Rezvanfar, Mohammad Abdollahi, Fakher Rahim

      Pages 3-16

   3. Secretome: Pharmaceuticals for Cell-Free Regenerative Therapy

      • Nazmul Haque, Basri Johan Jeet Abdullah, Noor Hayaty Abu Kasim

      Pages 17-35

   4. Preparation of Extracellular Vesicles from Mesenchymal Stem Cells

      • Fernanda Ferreira Cruz, Ligia Lins de Castro, Patricia Rieken Macedo Rocco

      Pages 37-51

   5. Exosomes for Regeneration, Rejuvenation, and Repair

      • Joydeep Basu, John W. Ludlow

      Pages 53-75

   6. Proinflammatory Cytokines Significantly Stimulate Extracellular Vesicle Production by Adipose-Derived and Umbilical Cord-Derived Mesenchymal Stem Cells

      • Phuc Van Pham, Ngoc Bich Vu, Khanh Hong-Thien Bui, Liem Hieu Pham

      Pages 77-90

3. Stem Cells

   1. Front Matter

      Pages 91-91

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   2. Evolution of Stem Cell Products in Medicine: Future of Off-the-Shelf Products

      • Phuc Van Pham, Hoa Trong Nguyen, Ngoc Bich Vu

      Pages 93-118

   3. Off-the-Shelf Mesenchymal Stem Cell Technology

      • Ngoc Bich Vu, Phuong Thi-Bich Le, Nhat Chau Truong, Phuc Van Pham

      Pages 119-141

   4. Ethical and Legal Issues of Cord Blood Stem Cell Banking

      • Luciana Riva, Giovanna Floridia, Carlo Petrini

      Pages 143-152

4. Back Matter

   Pages 153-157

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This invaluable resource discusses the current revolution in stem cell-based drugs and their potential use in clinical applications. Each chapter is contributed by a pre-eminent scientist in the field. An introductory section presents current stem cell drugs and stem cell-based products and a discussion of production, quality control, mechanisms, and efficacy. Following sections include discussions on stem cell-derived microvesicles based products, and derived exosomes based products. 
Stem Cell Drugs - A New Generation of Biopharmaceuticals and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering. This groundbreaking volume is also essential reading for those researching or studying drug development or pharmaceutical science. 

• angiogenesis
• exosomes
• MSC
• microvesicles
• musculoskeletal regeneration

• Laboratory of Stem Cell Research & Application, University of Science, Vietnam National University, Ho Chi Minh, Vietnam

  Phuc Van Pham

Phuc Van Pham received his Ph.D. in Human Physiology from Vietnam National University, Ho Chi Minh City, Vietnam. He is currently a Professor of Biology at Vietnam National University and Acting Director of the Laboratory of Stem Cell Research and Application. He is a longstanding lecturer and translational scientist at the University, and is a member of several societies and journal editorial boards focused on stem cells.

Dr. Pham and his colleagues have established one of the first multidisciplinary stem cell centers in Vietnam, and he has successfully launched an array of technologies in stem cell isolations. His research interests include stem cell isolation, stem cell therapy, mesenchymal stem cells, cancer stem cells, immunotherapy and regenerative medicine and he has published extensively in these areas.


After many years of experience as an embryologist, cell biologist, and molecular biologist, collaborating with leading researchers in Singapore, Japan, and the United States, Dr. Pham is a student again, keen to reach beyond the traditional boundaries of biology.

Policies and ethics