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Alagille Syndrome

Pathogenesis and Clinical Management

  • Book
  • © 2018

Overview

Editors:
  1. Binita M. Kamath

    1. Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Canada

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  2. Kathleen M. Loomes

    1. Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a concise yet comprehensive overview of Alagille syndrome
  • Outlines management challenges, strategies, and future treatment options
  • Written by experts in the field

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Alagille Syndrome: Overview and Introduction

    • David A. Piccoli
    Pages 1-9

  3. Bile Duct Development and the Notch Signaling Pathway

    • Stacey S. Huppert, Kathleen M. Campbell
    Pages 11-31

  4. Genetics of Alagille Syndrome

    • Melissa A. Gilbert, Nancy B. Spinner
    Pages 33-48

  5. Liver Disease in Alagille Syndrome

    • Alyssa Kriegermeier, Andrew Wehrman, Binita M. Kamath, Kathleen M. Loomes
    Pages 49-65

  6. Transplant Considerations in Alagille Syndrome

    • Evelyn Hsu, Elizabeth Rand
    Pages 67-76

  7. Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome

    • Justin T. Tretter, Doff B. McElhinney
    Pages 77-90

  8. Vascular Manifestations in Alagille Syndrome

    • Shannon M. Vandriel, Rebecca N. Ichord, Binita M. Kamath
    Pages 91-102

  9. The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development

    • RenĂ© Romero
    Pages 103-120

  10. Skeletal Involvement in Alagille Syndrome

    • Yadav Wagley, Troy Mitchell, Jason Ashley, Kathleen M. Loomes, Kurt Hankenson
    Pages 121-135

  11. Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype

    • Alastair Baker
    Pages 137-157

  12. Health-Related Quality of Life and Neurocognition in Alagille Syndrome

    • Saeed Mohammad, Estella M. Alonso
    Pages 159-165

  13. Future Therapeutic Approaches for Alagille Syndrome

    • Emma R. Andersson
    Pages 167-193

  14. Back Matter

    Pages 195-198
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Keywords

About this book

This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.


Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.  

Editors and Affiliations

  • Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Canada

    Binita M. Kamath

  • Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, USA

    Kathleen M. Loomes

About the editors

Binita M. Kamath, MBBChir MRCP MTR
The Hospital for Sick Children
Division of Gastroenterology, Hepatology and Nutrition 
Toronto, ON
Canada


Kathleen M. Loomes, MD
Children’s Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition
Department of Pediatrics
Philadelphia, PA
USA

 

Bibliographic Information

  • Book Title: Alagille Syndrome

  • Book Subtitle: Pathogenesis and Clinical Management

  • Editors: Binita M. Kamath, Kathleen M. Loomes

  • DOI: https://doi.org/10.1007/978-3-319-94571-2

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-94570-5Published: 09 October 2018

  • Softcover ISBN: 978-3-030-06878-3Published: 08 January 2019

  • eBook ISBN: 978-3-319-94571-2Published: 26 September 2018

  • Edition Number: 1

  • Number of Pages: XIV, 198

  • Number of Illustrations: 10 b/w illustrations, 31 illustrations in colour

  • Topics: Gastroenterology, Hepatology, Cardiology

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