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Voltage-gated Sodium Channels: Structure, Function and Channelopathies

  • Book
  • © 2018

Overview

Editors:
  1. Mohamed Chahine

    1. CERVO Brain Research Center, Institut Universitaire en Santé Mentale, Quebec, Canada

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  • Reviews exhaustively the key recent research into Na+ channels and related diseases
  • Broadens our understanding on Na+ channels and their associated diseases
  • Summarizes the latest studies on the physiopathology of Na+ channels

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 246)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
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  2. Evolution of Voltage-Gated Sodium Channels

    1. Front Matter

      Pages 1-1
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    2. Evolutionary History of Voltage-Gated Sodium Channels

      • Atsuo Nishino, Yasushi Okamura
      Pages 3-32

    3. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits

      • Steven Molinarolo, Daniele Granata, Vincenzo Carnevale, Christopher A. Ahern
      Pages 33-49

  3. The Structural Basis of Sodium Channel Function

    1. Front Matter

      Pages 51-51
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    2. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective

      • Tamer M. Gamal El-Din, Michael J. Lenaeus, William A. Catterall
      Pages 53-72

    3. The Cardiac Sodium Channel and Its Protein Partners

      • Elise Balse, Catherine Eichel
      Pages 73-99

    4. Posttranslational Modification of Sodium Channels

      • Zifan Pei, Yanling Pan, Theodore R. Cummins
      Pages 101-124

    5. Sodium Channel Trafficking

      • A. Mercier, P. Bois, A. Chatelier
      Pages 125-145

    6. pH Modulation of Voltage-Gated Sodium Channels

      • Colin H. Peters, Mohammad-Reza Ghovanloo, Cynthia Gershome, Peter C. Ruben
      Pages 147-160

    7. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C

      • Ademuyiwa S. Aromolaran, Mohamed Chahine, Mohamed Boutjdir
      Pages 161-184

  4. Drugs and Toxins Interactions with Sodium Channels

    1. Front Matter

      Pages 185-185
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    2. Toxins That Affect Voltage-Gated Sodium Channels

      • Yonghua Ji
      Pages 187-207

    3. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels

      • M. E. O’Leary, M. Chahine
      Pages 209-231

    4. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels

      • Alessandro Farinato, Concetta Altamura, Jean-François Desaphy
      Pages 233-250

    5. Structural Models of Ligand-Bound Sodium Channels

      • Boris S. Zhorov
      Pages 251-269

    6. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7

      • Jian Payandeh, David H. Hackos
      Pages 271-306

  5. Pathophysiology of Sodium Channels

    1. Front Matter

      Pages 307-307
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    2. Sodium Channelopathies of Skeletal Muscle

      • Stephen C. Cannon
      Pages 309-330

    3. Cardiac Arrhythmias Related to Sodium Channel Dysfunction

      • Eleonora Savio-Galimberti, Mariana Argenziano, Charles Antzelevitch
      Pages 331-354
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Keywords

About this book

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Editors and Affiliations

  • CERVO Brain Research Center, Institut Universitaire en Santé Mentale, Quebec, Canada

    Mohamed Chahine

About the editor

Dr. Mohamed Chahine is a Professor at the Department of Medicine of Université Laval and Head of the Laboratory of Cellular Electrophysiology at the CERVO Brain Research Center of the Institut universitaire en santé mentale de Québec. He has published over 160 articles in refereed journals as well as several book chapters in the field of voltage-gated Na+ channels and related diseases. Dr. Chahine has served or is currently serving on various committees of the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada. He is associate editor of Frontiers Journal and editor of Scientific Reports. He is a member of the editorial boards of the Canadian Journal of Cardiology (Canada), the World Journal of Cardiology (China), the Journal of Cardiovascular Research (USA), Advances in Bioscience and Biotechnology (USA), and the Journal of Cardiology and Therapy (Hong Kong). He has also organized several national and International symposia and workshops on the role ofion channels in disease. Dr. Chahine has been invited to present his research at several national and international conferences and academic institutions.

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