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Ex Vivo Engineering of the Tumor Microenvironment

  • Book
  • © 2017

Overview

Editors:
  1. Amir R. Aref

    1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. David Barbie

    1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Outlines how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo
  • Aids in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context
  • Opens new avenues for drug screening and biomarker development
  • Accelerates the preclinical evaluation of novel personalized medicine strategies for patients in real time
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introduction to Ex Vivo Cancer Models

    • Russell W. Jenkins
    Pages 1-12

  3. Patient-Derived Xenografts in Oncology

    • Dennis O. Adeegbe, Yan Liu
    Pages 13-40

  4. Organoid Culture: Applications in Development and Cancer

    • Israel Cañadas, David A. Barbie
    Pages 41-54

  5. Microfluidics and Future of Cancer Diagnostics

    • Samira Jamalian, Mohammad Jafarnejad, Amir R. Aref
    Pages 55-70

  6. Advancing Techniques and Insights in Circulating Tumor Cell (CTC) Research

    • Bee Luan Khoo, Parthiv Kant Chaudhuri, Chwee Teck Lim, Majid Ebrahimi Warkiani
    Pages 71-94

  7. The Cancer Secretome

    • Michaela Bowden
    Pages 95-120

  8. The Importance of Circulating Tumor Cells and Tumor Models in Future of Cancer Therapy

    • Babak Behnam, Hassan Fazilaty, Ali Roghanian
    Pages 121-135
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Keywords

About this book

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Editors and Affiliations

  • Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA

    Amir R. Aref, David Barbie

About the editors

Amir R. Aref, PhD, is Instructor, Dana-Farber Cancer Institute, Harvard Medical School.

Bibliographic Information

  • Book Title: Ex Vivo Engineering of the Tumor Microenvironment

  • Editors: Amir R. Aref, David Barbie

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-3-319-45397-2

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-45395-8Published: 16 December 2016

  • Softcover ISBN: 978-3-319-83282-1Published: 30 April 2018

  • eBook ISBN: 978-3-319-45397-2Published: 09 December 2016

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: IX, 135

  • Number of Illustrations: 1 b/w illustrations, 17 illustrations in colour

  • Topics: Cancer Research

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