Overview
- Nominated as an outstanding PhD thesis by the University of Genoa, Italy
- Presents a powerful in vitro model of neuronal network dynamics
- implementation of bio-hybrid microsystems for network electrophysiology
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (7 chapters)
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Front Matter
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Scientific and Technical Background
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Front Matter
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A New In Vitro Model: 3D Neural Networks Coupled to MEA Devices
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Front Matter
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Additional Applications with MEA Technology
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Front Matter
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Discussion and Conclusion
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Front Matter
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Back Matter
Keywords
About this book
The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.
Authors and Affiliations
Bibliographic Information
Book Title: Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems
Authors: Monica Frega
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-30237-9
Publisher: Springer Cham
eBook Packages: Engineering, Engineering (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-30236-2Published: 10 March 2016
Softcover ISBN: 978-3-319-80758-4Published: 25 April 2018
eBook ISBN: 978-3-319-30237-9Published: 01 March 2016
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIII, 148
Number of Illustrations: 54 b/w illustrations, 43 illustrations in colour
Topics: Biomedical Engineering and Bioengineering, Cell Physiology, Electronics and Microelectronics, Instrumentation, Neurosciences