Measuring Biological Impacts of Nanomaterials

1. Front Matter

   Pages i-ix

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2. Characterization of Nanoparticles Under Physiological Conditions

   • K. A. Eslahian, T. Lang, C. Bantz, R. Keller, R. Sperling, D. Docter et al.

   Pages 1-29

3. Probing the Cytotoxicity of Nanoparticles: Experimental Pitfalls and Artifacts

   • Jenny Domey, Lisa Haslauer, Ina Grau, Claudia Strobel, Melanie Kettering, Ingrid Hilger

   Pages 31-44

4. Monitoring the Impact of Nanomaterials on Animal Cells by Impedance Analysis: A Noninvasive, Label-Free, and Multimodal Approach

   • Michaela Sperber, Christina Hupf, Michael-M. Lemberger, Barbara Goricnik, Nadja Hinterreiter, Sonja Lukic et al.

   Pages 45-108

5. Interaction of Nanoparticles with Lipid Monolayers and Lung Surfactant Films

   • Mridula Dwivedi, Amit Kumar Sachan, Hans-Joachim Galla

   Pages 109-133

6. Carbon Nanodots: Synthesis, Characterization, and Bioanalytical Applications

   • Michael-M. Lemberger, Thomas Hirsch, Joachim Wegener

   Pages 135-175

7. Nanoparticles in Biomedical Applications

   • Jacqueline Maximilien, Selim Beyazit, Claire Rossi, Karsten Haupt, Bernadette Tse Sum Bui

   Pages 177-210

8. Back Matter

   Pages 211-214

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This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely.

This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicityassays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.

• Measuring
• Biological
• Impact
• Nanomaterials
• Bioanalytical

“I want to stress in clarity of the text, each chapter having also a generous and useful bibliography. The book is also wel illustrated, having 100 illustrations from which 56 are in colour. The index contains useful terms, being a true tool for the reader. … This book is a useful tool for students as well as for already mature professionals in the field of nanotechnology, medicine, biology in general.” (Ioan I. Ardelean, Romanian Journal of Biology, Vol. 63 (1-2), 2018)



“The book ‘Measuring Biological Impacts of Nanomateri­als’ is a very good guide-book for readers interested in recent advances in biomedical nanotechnology research. … The book provides excellent overview of our knowledge on modern scientific techniques and model systems for studying impact of nanomaterials as drug delivery vehicles in biomedi­cine which is essential for application of nanoparticle targeted therapy in the near future.” (Andrea Babelova, Neoplasma, Vol. 64 (1), 2017)

• University of Regensburg, Regensburg, Germany

  Joachim Wegener

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