Precision Molecular Pathology of Bladder Cancer

1. Front Matter

   Pages i-ix

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2. Molecular Pathology of Bladder Cancer: Current Understanding and Application

   1. Front Matter

      Pages 1-1

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   2. Risk Factors and Molecular Features Associated with Bladder Cancer Development

      • Anirban P. Mitra, Georg Bartsch Jr., Richard J. Cote

      Pages 3-28

   3. Grading, Staging, and Morphologic Risk Stratification of Bladder Cancer

      • Brian D. Robinson, Francesca Khani

      Pages 29-42

   4. Genomic Assessment of Muscle-Invasive Bladder Cancer: Insights from the Cancer Genome Atlas (TCGA) Project

      • Jaegil Kim, Gordon Robertson, Rehan Akbani, Seth P. Lerner, John N. Weinstein, Gad Getz et al.

      Pages 43-64

   5. Molecular Alterations in the Pathogenesis of Bladder Cancer Subtypes and Urothelial Carcinoma Variants

      • Hikmat Al-Ahmadie, Gopa Iyer

      Pages 65-83

   6. Treatment Paradigms in Bladder Cancer: Clinical Implications of Histological and Molecular Analysis

      • Mehrad Adibi, Colin P. Dinney

      Pages 85-101

   7. Requisite for Collection and Distribution of Tissue and Fluid Specimens for Molecular Diagnostics and Discovery in Bladder Cancer

      • Adrie van Bokhoven, M. Scott Lucia

      Pages 103-116

   8. Diagnostic, Prognostic, and Predictive Biomarkers on Bladder Tissue and Blood

      • Ryan Hutchinson, Yair Lotan

      Pages 117-136

   9. Urine Cytology and Existing Urinary Biomarkers for Bladder Cancer

      • Thomas A. Longo, Steven C. Brousell, Brant A. Inman

      Pages 137-155

3. Emerging Concepts in the Molecular Basis of Bladder Cancer Diagnosis and Therapy

   1. Front Matter

      Pages 157-157

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   2. Molecular Targeted Therapy of Bladder Cancer

      • Elizabeth R. Kessler, Dan Theodorescu, Thomas W. Flaig

      Pages 159-180

   3. Response to Immunotherapy: Application of Molecular Pathology to Predict Successful Response

      • Noah M. Hahn, Donna E. Hansel

      Pages 181-194

   4. Emerging Molecular Approaches in the Analysis of Urine in Bladder Cancer Diagnosis

      • James P. Solomon, A. Karim Kader, Donna E. Hansel

      Pages 195-207

   5. Stromal Contributions to Tumor Progression in Urothelial Carcinoma of the Bladder

      • Morgan Cowan, Daniel Miller, Alexander S. Baras

      Pages 209-220

   6. Modeling Bladder Cancer with Genetic Engineering: Fidelity of Human-to-Laboratory Models

      • Xue-Ru Wu

      Pages 221-237

4. Back Matter

   Pages 239-243

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This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.

• Adenocarcinoma
• Micropapillary Urothelial Carcinoma
• Multifocal Disease
• Papillary Urothelial Neoplasia
• Papilloma
• Squamous Cell Carcinoma

• Department of Pathology, University of California San Diego, San Diego, USA

  Donna E. Hansel

• Scott Department of Urology, Baylor College of Medicine, Houston, USA

  Seth P. Lerner

Donna E. Hansel MD PhD
Professor, UCSD Department of Pathology
Chief, Division of Anatomic Pathology
9500 Gilman Drive, MC 0612
La Jolla, CA 92093





Seth P. Lerner, MD, FACS
Professor, Scott Department of Urology
Beth and Dave Swalm Chair in Urologic Oncology 
Director of Urologic Oncology
Director of the Multidisciplinary Bladder Cancer Program
Faculty Group Practice Medical Director 
Co-Editor in Chief Bladder Cancer
Baylor College of Medicine Medical Center
7200 Cambridge, MC BCM380 
Houston, Texas  77030

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