Skip to main content
SpringerLink
Log in
Book cover

Extracellular Matrix in Tumor Biology

  • Book
  • © 2017

Overview

Editors:
  1. Rolf A. Brekken

    1. Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center , Dallas, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Dwayne Stupack

    1. Department of Reproductive Medicine, University of California , La Jolla, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Gives an overview on influence of Extracellular Matrix on tumor progression
  • Highlights modelling approaches leading to a better understanding of disease mechanisms
  • A useful source of information for researchers and medical doctors alike

Part of the book series: Biology of Extracellular Matrix (BEM)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (6 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The Extracellular Matrix of Tumors: A Focus on Fibronectin and Fibulin-5

    • Mary Topalovski, Rolf A. Brekken
    Pages 1-15

  3. Internalization of Collagen: An Important Matrix Turnover Pathway in Cancer

    • Dorota Ewa Kuczek, Mie Linder Hübbe, Daniel Hargbøl Madsen
    Pages 17-38

  4. Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression

    • Michael Pratt, Ya’an Kang, Xinqun Li, Jason B. Fleming
    Pages 39-49

  5. Versican: Role in Cancer Tumorigenesis

    • Paul A. Keire, Inkyung Kang, Thomas N. Wight
    Pages 51-74

  6. Engineering Advanced Models of the Glioblastoma Microenvironment Using Biomaterials

    • Andrew Rape, Sanjay Kumar
    Pages 75-89

  7. Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way

    • Daniel Keeley, David R. Sherwood
    Pages 91-115
Back to top

Keywords

About this book

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression.  The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Editors and Affiliations

  • Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center , Dallas, USA

    Rolf A. Brekken

  • Department of Reproductive Medicine, University of California , La Jolla, USA

    Dwayne Stupack

About the editors

​Rolf Brekken is Professor of Surgery and Pharmacology and Deputy Director of the Hamon Center Therapeutic Oncology Research at UT Southwestern. Dr. Brekken’s laboratory studies ECM signaling in tumors, therapeutic immune reactivation and how immune cells contribute to the metastatic cascade. He has authored over 150 peer-reviewed publications and is currently a senior editor at Cancer Research. 

Dwayne Stupack is an associate professor of Reproductive Medicine and Pathology at the University of California San Diego, Moore’s Cancer Center.  Dr. Stupack’s laboratory work has been focused on the intersection of extracellular matrix signaling, the presentation of different forms of the same matrix to cells, and cell survival during tumor metastasis.  A past councilor of the American Society for Matrix Biology with more than 90 publications, Dr. Stupack currently edits the Society’s Matrix Letter.

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation