Molecular Oncology: Underlying Mechanisms and Translational Advancements

1. Front Matter

   Pages i-x

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2. Legacy of Vitamin D: Role of Vitamin D in Prevention of Gynecological Cancers

   • Rukset Attar, Maria Luisa Gasparri, Talha Abdul Halim, Dana Al Hamwi, Ilknur Ucak, Sundas Fayyaz et al.

   Pages 1-14

3. Microtubule Targeting Agents in Cancer Therapy: Elucidating the Underlying Molecular Mechanisms

   • Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Mohd. Rais Mustafa

   Pages 15-65

4. New Challenges in Cancer Therapy: MAPK Inhibitors from Bench to Bedside

   • Catherine Ropert, Hugo W. Huth

   Pages 67-91

5. Adenosine Signaling Pathways as Potential Therapeutic Targets in Prostate Cancer Disease

   • Silvia Novío, María Jesús Núñez-Iglesias, Manuel Freire-Garabal

   Pages 93-107

6. Emerging Role of ncRNAs in Cancer Biology: Techniques for Diagnostic Monitoring and Potential ncRNA-Based Therapies

   • Palmiro Poltronieri, Oscar F. D’Urso, Massimo Mallardo

   Pages 109-128

7. Exosomes: New Biomarkers for Targeted Cancer Therapy

   • Chiara Martinelli

   Pages 129-157

8. Targeting of EGFR Induced Signaling Network in Hepatocellular Carcinoma

   • Aliye Aras Perk, Riffat Batool, Sobia Kanwal, Edyta Pawlak-Adamska, Oskar Nowak, Muhammad Sheeraz Ahmad et al.

   Pages 159-171

9. Targeting of Heat Shock Proteins by Natural Products in Cancer

   • Evren Önay Uçar, Murat Pekmez, Nazlı Arda

   Pages 173-192

10. The Immunobiology of Cancer: From Tumor Escape to Cancer Immunoediting Towards Immunotherapy in Gynecologic Oncology

    • Maria Luisa Gasparri, Ilary Ruscito, Katayoun Taghavi, Ammad Ahmad Farooqi, Andrea Papadia, Chiara Focaccetti et al.

    Pages 193-204

11. Investigation of Androgen Receptor Signaling Pathways with Epigenetic Machinery in Prostate Cancer

    • Ken-ichi Takayama, Satoshi Inoue

    Pages 205-222

12. Adenoid Cystic Carcinoma of the Lacrimal Gland: Clinical, Genetic and Molecular Characteristics

    • Steven Pappas, Ke Jin, Brian C. Tse, David T. Tse, Daniel Pelaez, Wensi Tao

    Pages 223-236

13. Role of TRAIL and miR-34a as Therapeutic Agents in Prostate Cancer: Increasing the Armory of Micro-Musketeers

    • Agnieszka Sobczak-Kupiec, Muhammad Javed Iqbal, Muhammad Zahid Qureshi, Qaisar Mansoor, Seyed Mohammad Nabavi, Jelena Purenovic et al.

    Pages 237-245

14. Components from the Traditional Chinese Medicine Acts as Protein Kinase Inhibitors

    • Minghua Liu, Ge Zhao, Shousong Cao, Yangyang Zhang, Xiaofang Li, Xiukun Lin

    Pages 247-272

15. Impact and Application of Nutraceuticals on Inflammation-Induced Colorectal Cancer Development

    • Yi Liu

    Pages 273-291

16. Back Matter

    Pages 293-300

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Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. 


Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

• Adenosine signaling pathways
• Blood-based cancer detection
• Cancer therapy
• Exosomes
• Microtubule targeting agents
• Non-coding RNA
• Oncology
• Virus caused cancer

• Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

  Ammad Ahmad Farooqi, Muhammad Ismail

Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.

Professor Muhammad Ismail has a Ph.D. in Biotechnology and is currently the Director of the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad. His main focus of research is Cancer Genetics and Therapeutics, Nanomedicine and Pharmacogenomics.

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