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Platelets in Thrombotic and Non-Thrombotic Disorders

Pathophysiology, Pharmacology and Therapeutics: an Update

  • Book
  • © 2017

Overview

Editors:
  1. Paolo Gresele

    1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

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  2. Neal S. Kleiman

    1. Houston Methodist Hospital , Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. José A. Lopez

    1. Bloodworks Northwest, University of Washington , Seattle, USA

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  4. Clive P. Page

    1. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Updates on recent developments in this rapidly expanding field
  • Provides a detailed review of current science and application in the fields of thrombosis and hemostasis
  • An authoritative reference work for researchers and clinicians

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Table of contents (97 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Physiology

    1. Front Matter

      Pages 1-1
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    2. A Brief History of Blood Platelets: A Personal View

      • Michael C. Berndt, Pat Metharom, Robert K. Andrews
      Pages 3-9

    3. Phylogeny of Blood Platelets

      • Stefania Momi, Viroj Wiwanitkit
      Pages 11-19

    4. Platelet Morphology and Ultrastructure

      • Harry F. G. Heijnen, Suzanne J. A. Korporaal
      Pages 21-37

    5. Megakaryocyte Development and Platelet Production

      • Joseph E. Italiano Jr.
      Pages 39-53

    6. Platelet Heterogeneity

      • Shawn Jobe
      Pages 55-67

    7. Regulation of Platelet Adhesion Receptors

      • Ana Kasirer-Friede, Sanford J. Shattil
      Pages 69-84

    8. The Platelet Glycoprotein Ib-IX-V Complex

      • José A. López
      Pages 85-97

    9. αIIbβ3 (GPIIb/IIIa) Structure and Function

      • Joel S. Bennett
      Pages 99-112

    10. GPVI

      • Yacine Boulaftali, Benoit Ho Tin Noé, Martine Jandrot-Perrus, Pierre H. Mangin
      Pages 113-127

    11. The Role of CLEC-2 in and Beyond the Vasculature

      • Julie Rayes, Alexander T. Hardy, Stephanie E. Lombard, Samantha J. Montague, Steve P. Watson, Kate L. Lowe
      Pages 129-138

    12. Anatomy of the Platelet Cytoskeleton

      • Hervé Falet
      Pages 139-156

    13. Platelet Proteomics and its Applications to Study Platelet-Related Disorders

      • Michela Di Michele, Kris Gevaert, Kathleen Freson
      Pages 157-170

    14. The Platelet PARs

      • Amal Arachiche, Marvin T. Nieman
      Pages 171-185

    15. The P2 Receptors

      • Béatrice Hechler, Christian Gachet
      Pages 187-202

    16. Platelet Prostanoids and their receptors

      • Susanne Fries, Tilo Grosser
      Pages 203-211

    17. Platelet Genomics

      • Zongdong Li, Dmitri V. Gnatenko, Wadie F. Bahou
      Pages 213-226

    18. The Platelet Transcriptome: Coding RNAs

      • Jesse W. Rowley, Bhanu Kanth Manne, Andrew S. Weyrich
      Pages 227-238

    19. Noncoding RNAs in Platelet Biology

      • Leonard C. Edelstein, Paul F. Bray
      Pages 239-252
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Keywords

About this book

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Editors and Affiliations

  • Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  • Houston Methodist Hospital , Houston, USA

    Neal S. Kleiman

  • Bloodworks Northwest, University of Washington , Seattle, USA

    José A. Lopez

  • Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

About the editors

Paolo Gresele, Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy


Neil S. Kleiman, Houston Methodist Hospital, TX, USA


José A. Lopez, Bloodworks Northwest, University of Washington, Seattle, WA, USA


Clive P. Page, Sackler Institute of Pulmonary Pharmacology, King’s College London, UK

Bibliographic Information

  • Book Title: Platelets in Thrombotic and Non-Thrombotic Disorders

  • Book Subtitle: Pathophysiology, Pharmacology and Therapeutics: an Update

  • Editors: Paolo Gresele, Neal S. Kleiman, José A. Lopez, Clive P. Page

  • DOI: https://doi.org/10.1007/978-3-319-47462-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-47460-1Published: 17 March 2017

  • Softcover ISBN: 978-3-319-83741-3Published: 06 September 2018

  • eBook ISBN: 978-3-319-47462-5Published: 08 March 2017

  • Edition Number: 1

  • Number of Pages: XIII, 1445

  • Number of Illustrations: 20 b/w illustrations, 20 illustrations in colour

  • Topics: Pharmacology/Toxicology, Hematology, Human Physiology, Cardiology, Molecular Medicine

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