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The Actin Cytoskeleton

  • Book
  • © 2017

Overview

Editors:
  1. Brigitte M. Jockusch

    1. Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

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  • Provides an up-to-date handbook on the organisation and dynamics of actin and the interaction with its companions
  • Presents the cutting-edge view on the role of the actin cytoskeleton in signalling pathways
  • Features the hot-topic research on the activity of toxins, viral and bacterial pathogens on the actin cytoskeleton
  • Introduces the present knowledge on the activity of actin on chromatin organisation, transcription and RNA transport

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 235)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Mammalian Actins: Isoform-Specific Functions and Diseases

    • Christophe Ampe, Marleen Van Troys
    Pages 1-37

  3. Assembly and Maintenance of Myofibrils in Striated Muscle

    • Joseph W. Sanger, Jushuo Wang, Yingli Fan, Jennifer White, Lei Mi-Mi, Dipak K. Dube et al.
    Pages 39-75

  4. Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions

    • Thomas A. Masters, John Kendrick-Jones, Folma Buss
    Pages 77-122

  5. Actin Filament Structures in Migrating Cells

    • Jaakko Lehtimäki, Markku Hakala, Pekka Lappalainen
    Pages 123-152

  6. Signalling Pathways Controlling Cellular Actin Organization

    • Anika Steffen, Theresia E. B. Stradal, Klemens Rottner
    Pages 153-178

  7. ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins

    • Klaus Aktories, Carsten Schwan, Alexander E. Lang
    Pages 179-206

  8. Common Themes in Cytoskeletal Remodeling by Intracellular Bacterial Effectors

    • Guy Tran Van Nhieu, Stéphane Romero
    Pages 207-235

  9. Viruses That Exploit Actin-Based Motility for Their Replication and Spread

    • N. Bishara Marzook, Timothy P. Newsome
    Pages 237-261

  10. Multiscale View of Cytoskeletal Mechanoregulation of Cell and Tissue Polarity

    • Chen Luxenburg, Benjamin Geiger
    Pages 263-284

  11. Molecular Control of Actin Dynamics In Vivo: Insights from Drosophila

    • Lena Brüser, Sven Bogdan
    Pages 285-310

  12. From Cytoskeleton to Gene Expression: Actin in the Nucleus

    • Tiina Viita, Maria K. Vartiainen
    Pages 311-329

  13. What We Know and Do Not Know About Actin

    • Thomas D. Pollard
    Pages 331-347

  14. Back Matter

    Pages 349-351
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Keywords

About this book

Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics  and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on  "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

Editors and Affiliations

  • Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

    Brigitte M. Jockusch

Bibliographic Information

  • Book Title: The Actin Cytoskeleton

  • Editors: Brigitte M. Jockusch

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-319-46371-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-46369-8Published: 12 January 2017

  • Softcover ISBN: 978-3-319-83503-7Published: 07 July 2018

  • eBook ISBN: 978-3-319-46371-1Published: 03 January 2017

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XII, 352

  • Number of Illustrations: 30 b/w illustrations, 30 illustrations in colour

  • Topics: Pharmacology/Toxicology, Cell Physiology

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