Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

1. Front Matter

   Pages i-vi

   PDF

2. Mechanisms of Normal Tissue Response

   • Jolinta Y. Lin, Isabel L. Jackson, Zeljko Vujaskovic

   Pages 1-28

3. The Role of Hypoxia in Radiation Response

   • Monica M. Olcina, Ryan Kim, Amato J. Giaccia

   Pages 29-42

4. The Role of Cancer Stem Cells in Tumour Radioresponse

   • Annett Linge, Anna Dubrovska, Michael Baumann, Mechthild Krause

   Pages 43-74

5. Novel Strategies to Prevent, Mitigate or Reverse Radiation Injury and Fibrosis

   • Pierre Montay-Gruel, Gael Boivin, Marie-Catherine Vozenin

   Pages 75-108

6. Technology Based Strategies to Enhance the Therapeutic Ratio

   • David V. Fried, Shiva K. Das

   Pages 109-138

7. Nitric Oxide Synthase Uncoupling in Tumor Progression and Cancer Therapy

   • Ross B. Mikkelsen, Vasily A. Yakovlev, Christopher S. Rabender, Asim Alam

   Pages 139-158

8. Aiming the Immune System to Improve the Antitumor Efficacy of Radiation Therapy

   • Chunqing Guo, Timothy Harris, Xiang-Yang Wang

   Pages 159-181

9. The Role of MicroRNAs in Modulating Tissue Response to Radiation

   • Rebecca J. Boohaker, Bo Xu

   Pages 183-193

10. Adapting Therapy Based on Tumor Response

    • Christina Hunter Chapman, Yue Cao, Martha Matuszak, Matt Schipper, Theodore S. Lawrence

    Pages 195-224

11. NQO1 Bioactivatable Drugs Enhance Radiation Responses

    • Erik A. Bey, Julia C. Meade, Molly A. Silvers, Edward A. Motea, Praveen L. Patidar, Rolf Brekken et al.

    Pages 225-252

12. DNA Repair Pathways as a Potential Target for Radiosensitization

    • Mahmoud Toulany

    Pages 253-287

13. Radiosensitizing Glioma by Targeting ATM with Small Molecule Inhibitors

    • Amrita Sule, Kristoffer Valerie

    Pages 289-305

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

• Bioactive Drugs
• Normal Tissues
• Radiation
• Therapeutic Ratio
• Tumor

• Department of Radiation Oncology Massey Cancer Center, Virginia Commonwealth University, Richmond, USA

  Mitchell S. Anscher, Kristoffer Valerie

Mitchell S. Anscher, MD, FACR, FACRO, FASTRO, is Professor, Department of Radiation Oncology, Virginia Commonwealth University School of Medicine.Kristoffer Valerie, PhD, is Professor, Division of Molecular Radiobiology, Department of Radiation Oncology, Co-Leader, Radiation Biology & Oncology Program, Massey Cancer Center, Virginia Commonwealth University. 

Policies and ethics