Editors:
- Comprehensive set of reviews dealing with cellular (tissue) and intracellular targeting of nanovehicles
- Covers classical and computational means of nanovehicle targeting
- Delivers important application areas in medicine
- Written by world experts in this field
Part of the book series: Fundamental Biomedical Technologies (FBMT)
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Table of contents (17 chapters)
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Front Matter
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Introductory Chapters
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Front Matter
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How to Extend the Circulation Time of Nanovehicles
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Front Matter
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Differences Between In Vivo Status in Men and Mice
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Front Matter
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Cell-Specific Targeting
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Front Matter
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About this book
The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies.
Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.
Editors and Affiliations
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Biomolecular and Chemical Engineering, Vanderbilt University Biomolecular and Chemical Engineering, Nashville, USA
Aleš Prokop
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Pharmaceutical Sciences, Midwestern University Pharmaceutical Sciences, GLENDALE, USA
Volkmar Weissig
Bibliographic Information
Book Title: Intracellular Delivery III
Book Subtitle: Market Entry Barriers of Nanomedicines
Editors: Aleš Prokop, Volkmar Weissig
Series Title: Fundamental Biomedical Technologies
DOI: https://doi.org/10.1007/978-3-319-43525-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-43523-7Published: 23 December 2016
Softcover ISBN: 978-3-319-82846-6Published: 12 July 2018
eBook ISBN: 978-3-319-43525-1Published: 31 October 2016
Series ISSN: 1559-7083
Series E-ISSN: 2626-8655
Edition Number: 1
Number of Pages: XIII, 453
Number of Illustrations: 16 b/w illustrations, 65 illustrations in colour
Topics: Biomedicine general, Nanotechnology