Overview
- First book devoted entirely to quantitative modeling of tumor microenvironment
- Includes examples of integration between math modeling and cancer experiments that can be followed in readers' research
- Gives the reader a compendium knowledge of a current state of the art in systems biology of tumor microenvironment
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 936)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be ofinterest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Editors and Affiliations
About the editor
PhD: Tulane University, Department of Mathematics, 2002
Postdoctoral Fellow: Mathematical Biosciences Institute, OSU, Columbus Ohio
Postdoctoral Researcher: University of Dundee, Scotland
Bibliographic Information
Book Title: Systems Biology of Tumor Microenvironment
Book Subtitle: Quantitative Modeling and Simulations
Editors: Katarzyna A. Rejniak
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-42023-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-42021-9Published: 24 October 2016
Softcover ISBN: 978-3-319-82480-2Published: 23 June 2018
eBook ISBN: 978-3-319-42023-3Published: 13 October 2016
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XVII, 249
Number of Illustrations: 13 b/w illustrations, 80 illustrations in colour
Topics: Cancer Research, Mathematical and Computational Biology, Biological and Medical Physics, Biophysics