Topological Interactions in Ring Polymers

1. Front Matter

   Pages i-xvi

   PDF

2. Introduction

   • Davide Michieletto

   Pages 1-10

3. Predicting the Behaviour of Rings in Solution

   • Davide Michieletto

   Pages 11-27

4. Molecular Dynamics Models

   • Davide Michieletto

   Pages 29-45

5. Threading Rings

   • Davide Michieletto

   Pages 47-78

6. A Bio-Physical Model for the Kinetoplast DNA

   • Davide Michieletto

   Pages 79-94

7. The Role of Topology in DNA Gel Electrophoresis

   • Davide Michieletto

   Pages 95-120

8. Conclusions

   • Davide Michieletto

   Pages 121-122

9. Back Matter

   Pages 123-124

   PDF

Ring polymers are one of the last big mysteries in polymer physics, and this thesis tackles the problem of describing their behaviour when interacting in dense solutions and with complex environments and reports key findings that help shed light on these complex issues. The systems investigated are not restricted to artificial polymer systems, but also cover biologically inspired ensembles, contributing to the broad applicability and interest of the conclusions reached. One of the most remarkable findings is the unambiguous evidence that rings inter-penetrate when in dense solutions; here this behaviour is shown to lead to the emergence of a glassy state solely driven by the topology of the constituents. This novel glassy state is unconventional in its nature and, thanks to its universal properties inherited from polymer physics, will attract the attention of a wide range of physicists in the years to come.
 

• Ring Molecules in Solution
• Molecular Dynamics Models of Rings
• Kinetoplast DNA
• Gel Electrophoresis
• DNA Knots
• Topological Glass
• Interpenetrating Ring Molecules
• DNA Gel Electrophoresis

• School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom

  Davide Michieletto

After his undergraduate studies in Padova (Italy) Davide Michieletto moved to the UK in 2011 where he attended the Doctoral Training Centre in Complexity Science at the University of Warwick until 2015. During this time he worked on a number of projects, the main one with Prof. Matthew Turner leading to his PhD in Physics and Complexity Science for a study of Topological Interactions in Ring Polymers.  In September 2015 he  became a Post-Doctoral Research Associate at the University of Edinburgh, working with Prof. Davide Marenduzzo on biophysical models for DNA and chromatin organisation in the cell nucleus.

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