Overview
- Focuses on potential targets/strategies for increasing the therapeutic ratio for radiotherapy
- Discusses radiotherapies with an integrated approach
- Highlights advances in approaches as well as the barriers to successful clinical application
- Includes supplementary material: sn.pub/extras
Part of the book series: Cancer Drug Discovery and Development (CDD&D)
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
About this book
In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.
Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).
Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
Editors and Affiliations
About the editors
Bibliographic Information
Book Title: Increasing the Therapeutic Ratio of Radiotherapy
Editors: Philip J. Tofilon, Kevin Camphausen
Series Title: Cancer Drug Discovery and Development
DOI: https://doi.org/10.1007/978-3-319-40854-5
Publisher: Humana Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2017
Hardcover ISBN: 978-3-319-40852-1Published: 25 November 2016
Softcover ISBN: 978-3-319-82201-3Published: 27 June 2018
eBook ISBN: 978-3-319-40854-5Published: 21 November 2016
Series ISSN: 2196-9906
Series E-ISSN: 2196-9914
Edition Number: 1
Number of Pages: VIII, 280
Number of Illustrations: 7 b/w illustrations, 34 illustrations in colour
Topics: Cancer Research, Radiotherapy, Drug Resistance