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Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology

  • Book
  • © 2016

Overview

Editors:
  1. Richard M. Kostrzewa

    1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Trevor Archer

    1. Department of Psychology, University of Gothenburg, Gothenburg, Sweden

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Highlights the major perinatal insults in animals that model human disorders
  • Describes actions and outcomes of notable neuroteratogens/neurotoxins that alter neuronal ontogeny
  • Provides a perspective towards experimental approaches in behavioral teratology
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 29)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Neuroteratology and Animal Modeling of Brain Disorders

    • Trevor Archer, Richard M. Kostrzewa
    Pages 1-40

  3. Perinatal Lesioning and Lifelong Effects of the Noradrenergic Neurotoxin 6-Hydroxydopa

    • Richard M. Kostrzewa
    Pages 43-50

  4. Selective Lifelong Destruction of Brain Monoaminergic Nerves Through Perinatal DSP-4 Treatment

    • Przemysław Nowak
    Pages 51-71

  5. Noradrenergic–Dopaminergic Interactions Due to DSP-4–MPTP Neurotoxin Treatments: Iron Connection

    • Trevor Archer
    Pages 73-86

  6. Perinatal Domoic Acid as a Neuroteratogen

    • Tracy A. Doucette, R. Andrew Tasker
    Pages 87-110

  7. Perinatal 192 IgG-Saporin as Neuroteratogen

    • Laura Petrosini, Paola De Bartolo, Debora Cutuli, Francesca Gelfo
    Pages 111-123

  8. NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems

    • Luisa Bracci-Laudiero, Maria Egle De Stefano
    Pages 125-152

  9. Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders

    • Eva M. Marco, Elena Velarde, Ricardo Llorente, Giovanni Laviola
    Pages 155-181

  10. Neurobehavioral Effects from Developmental Methamphetamine Exposure

    • Sarah A. Jablonski, Michael T. Williams, Charles V. Vorhees
    Pages 183-230

  11. Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases—an Overview of Experimental Studies

    • Anna Maria Tartaglione, Aldina Venerosi, Gemma Calamandrei
    Pages 231-264

  12. The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease

    • Darin J. Knapp, George R. Breese
    Pages 265-277

  13. Perinatal 6-Hydroxydopamine Modeling of ADHD

    • John P. Kostrzewa, Rose Anna Kostrzewa, Richard M. Kostrzewa, Ryszard Brus, Przemysław Nowak
    Pages 279-293

  14. Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems

    • Trevor Archer, Danilo Garcia
    Pages 295-311

  15. Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson’s Disease

    • John P. Kostrzewa, Rose Anna Kostrzewa, Richard M. Kostrzewa, Ryszard Brus, Przemysław Nowak
    Pages 313-332

  16. Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings

    • Trevor Archer, Richard M. Kostrzewa
    Pages 333-351

  17. Lifelong Rodent Model of Tardive Dyskinesia—Persistence After Antipsychotic Drug Withdrawal

    • Richard M. Kostrzewa, Ryszard Brus
    Pages 353-362

  18. Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism

    • Peter Ranger, Bart A. Ellenbroek
    Pages 363-386

  19. Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor

    • Russell W. Brown, Daniel J. Peterson
    Pages 387-402

  20. Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review

    • B. Grayson, S. A. Barnes, A. Markou, C. Piercy, G. Podda, J. C. Neill
    Pages 403-428
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Keywords

About this book

This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

Reviews

“This informative new book, written and edited by researchers in the field of the neuroteratology, presents the most recent data regarding how perinatal insults of various types can produce effects in the brain that persist throughout the lifespan. … The editors and chapter authors provide important information about toxic exposure during pregnancy. The target audience is ‘those engaged in studies in neuro- ontogeny; the book is also important collisions involved in the care of pregnant women or children.’” (Michael Joel Schrift, Doody's Book Reviews, December, 2016)

Editors and Affiliations

  • Department of Biomedical Sciences, East Tennessee State University, Johnson City, USA

    Richard M. Kostrzewa

  • Department of Psychology, University of Gothenburg, Gothenburg, Sweden

    Trevor Archer

Bibliographic Information

  • Book Title: Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology

  • Editors: Richard M. Kostrzewa, Trevor Archer

  • Series Title: Current Topics in Behavioral Neurosciences

  • DOI: https://doi.org/10.1007/978-3-319-34136-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-34134-7Published: 21 July 2016

  • Softcover ISBN: 978-3-319-81683-8Published: 07 June 2018

  • eBook ISBN: 978-3-319-34136-1Published: 13 July 2016

  • Series ISSN: 1866-3370

  • Series E-ISSN: 1866-3389

  • Edition Number: 1

  • Number of Pages: VIII, 446

  • Number of Illustrations: 40 b/w illustrations, 35 illustrations in colour

  • Topics: Neurosciences, Psychopharmacology, Neurobiology

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