Heat Shock Protein Inhibitors

1. Front Matter

   Pages i-vii

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2. Targeting the C-Terminus of Hsp90 as a Cancer Therapy

   • Jeanette McConnell, Yao Wang, Shelli McAlpine

   Pages 1-20

3. Hsp90 Co-chaperones as Drug Targets in Cancer: Current Perspectives

   • Adrienne L. Edkins

   Pages 21-54

4. Evaluating Dual Hsp90 and Hsp70 Inhibition as a Cancer Therapy

   • Laura K. Buckton, Yao Wang, Jeanette R. McConnell, Shelli R. McAlpine

   Pages 55-80

5. The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics

   • Alexandra Manos-Turvey, Jeffrey L. Brodsky, Peter Wipf

   Pages 81-129

6. Allosteric Inhibitors of Hsp70: Drugging the Second Chaperone of Tumorigenesis

   • Sharan R. Srinivasan, Hao Shao, Xiaokai Li, Jason E. Gestwicki

   Pages 131-162

7. Hsp40 Co-chaperones as Drug Targets: Towards the Development of Specific Inhibitors

   • Eva-Rachele Pesce, Gregory L. Blatch, Adrienne L. Edkins

   Pages 163-195

8. HSP47: The New Heat Shock Protein Therapeutic Target

   • George Sharbeen, Shelli McAlpine, Phoebe Phillips

   Pages 197-219

9. Heat Shock Protein 27: Structure, Function, Cellular Role and Inhibitors

   • Rashid Mehmood, Shelli R. McAlpine

   Pages 221-234

10. Back Matter

    Pages 235-238

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactionson the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

• Chemical Probes
• Dual Hsp70 Modulators
• Dual Hsp90 Modulators
• Heat Shock Proteins
• Hsp 40
• Hsp47
• Hsp70 Inhibitors
• Hsp70/hsp40 Interactions
• Hsp90
• Molecular Chaperones

• School of Chemistry, University of New South Wales, Sidney, Australia

  Shelli R. McAlpine

• Biomedical Biotechnology Research Unit (BioBRU); Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa

  Adrienne Lesley Edkins

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