Dupuytren Disease and Related Diseases - The Cutting Edge

1. Front Matter

   Pages i-xvii

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2. Epidemiology and Patients Views

   1. Front Matter

      Pages 1-1

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   2. Treatment of Dupuytren Disease in Different Countries: A Welcome Address from the President of IFSSH

      • Zsolt Szabó

      Pages 3-9

   3. The Epidemiology of Surgical Intervention for Dupuytren Contracture in England

      • Joseph J. Dias

      Pages 11-15

   4. Favorite Options of German Hand Surgeons in the Treatment of Dupuytren Disease

      • Bert Reichert, Magnus Baringer

      Pages 17-21

   5. Trends in Dupuytren Treatment in the United States

      • Scott Hadley, Emerson Floyd, John Zhao, Philip Blazar

      Pages 23-27

   6. International Patient Survey (Part 1: Dupuytren Disease)

      • Wolfgang Wach, Gary Manley

      Pages 29-40

3. Cellular and Extra-cellular Events, Pathogenesis

   1. Front Matter

      Pages 41-41

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   2. The Extracellular Matrix in Dupuytren Disease

      • David B. O’Gorman

      Pages 43-54

   3. Biomarkers of Postsurgical Outcome in Dupuytren Disease

      • Orla Jupp, Michael Pullinger, Tom Marjoram, Martin Lott, Adrian J. Chojnowski, Ian M. Clark

      Pages 55-61

   4. Tumour Necrosis Factor as a Therapeutic Target in Dupuytren Disease

      • Jagdeep Nanchahal, David Izadi

      Pages 63-71

   5. Contraction Versus Contracture: Considerations on the Pathogenesis of Dupuytren Disease

      • Hanno Millesi

      Pages 73-81

   6. Controversy: The Contracture in Dupuytren Disease Is an Active Process

      • Jagdeep Nanchahal, David Izadi

      Pages 83-87

   7. Controversy: The Contracture in Dupuytren Disease Is a Passive Process

      • Charles Eaton

      Pages 89-96

4. Genetics and Associations

   1. Front Matter

      Pages 97-97

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   2. Human Genetic Studies of Dupuytren Disease: A Primer

      • Roel A. Ophoff

      Pages 99-103

   3. Network Analysis and Fine-Mapping GWAS Loci to Identify Genes and Functional Variants Involved in the Development of Dupuytren Disease

      • Kerstin Becker, Juanjiangmeng Du, Peter Nürnberg, Hans Christian Hennies

      Pages 105-111

5. Collagenase Injection

   1. Front Matter

      Pages 113-113

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   2. Collagenase Injection: Journey from Bench to Current Advanced Clinical Use

      • Lawrence C. Hurst, Marie A. Badalamente, Kerri Kulovitz, Maria Relevo

      Pages 115-125

   3. Efficacy of Using Local Anesthesia Before Collagenase Injection in Reducing Overall Pain Experience in Patients Treated for Dupuytren Contracture: A Quasi-Randomized Study

      • Jesper Nordenskjöld, Eva Ahlgren, Johanna Waldau, Markus Waldén, Isam Atroshi

      Pages 127-129

In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed.  Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.

• collagenase injection
• hand therapy
• needle fasciotomy
• radiotherapy
• surgical techniques
• Radiaton Oncology

• University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

  Paul M. N. Werker

• Leicester General Hospital, University Hospitals of Leicester, Leicester, United Kingdom

  Joseph Dias

• Dupuytren Foundation, West Palm Beach, USA

  Charles Eaton

• Nürnberg Clinics, Paracelsus Medical University, Nürnberg, Germany

  Bert Reichert

• International Dupuytren Society, Übersee, Germany

  Wolfgang Wach

Paul Werker is Professor and Chair of the Department of Plastic Surgery of the University Medical Center Groningen, the Netherlands. He is a diplomate of European Board of Plastic Reconstructive and Aesthetic Surgery (EBOPRAS) and the Federation of European Societies for Surgery of the Hand (FESSH). He is lead or co-author of 86 peer-reviewed PubMed-listed papers and co-editor of the book Dupuytren's Disease and Related Hyperproliferative Disorders. He won the Esser Prize for his work on the foreskin free flap in 2000.

Joseph Dias is Professor in Hand and Orthopaedic Surgery and Head of the Academic Department of Musculoskeletal Surgery at the University Hospitals of Leicester, UK. He is also a consultant hand and orthopaedic surgeon for the University Hospitals of Leicester. He is a Fellow of the Royal College of Surgeons in Edinburgh. His special interests include epidemiology of hand and wrist disorders and Dupuytren’s contracture. He has published over 150 scientific articles and has authored multiple national reports and NICE-accredited clinical pathways.

Charles Eaton is a hand surgeon in West Palm Beach, Florida, USA. He is the founder and Executive Director of the Dupuytren Foundation, a US nonprofit organization. Dr. Eaton has worked in academic and private practice and developed a Dupuytren-centered practice, which he closed in 2012 to volunteer full time for the Dupuytren Foundation. He has authored articles and book chapters on a range of hand surgery topics, with an emphasis on Dupuytren disease. He currently serves on the advisory board of the International Dupuytren Society and the Canadian Dupuytren Society.

Bert Reichert is a Professor of Plastic Surgery at Paracelsus Medical University, Nürnberg, Germany. He practices at the Clinic for Plastic, Reconstructive, and Hand Surgery, Center for Severe Burn Injuries, Paracelsus Medical University and at Klinikum Nürnberg-Süd, Nürnberg. He is an  accredited specialist in General Surgery, Plastic Surgery, and Hand Surgery. His previous positions include Director of Plastic Surgery at Stadtlohn Hospital; Deputy Director, Department of Plastic Surgery, Burn Unit, University of Lübeck; and Associate Professor of Plastic Surgery, University of Regensburg.

Wolfgang Wach received his PhD in Solid State Physics from the University of Munich, Germany. After six years of research in ion implantation he worked in electronic design at Siemens and as General Manager at AT&T Microelectronics Europe. He started his own software company, CAL, in 1995 and the International Dupuytren Society (IDS) in 2003. IDS is a non-profit organization involving patients and physicians from all over the world who cooperate in providing information on Dupuytren disease, supporting patients, and finding a cure for the disease. Dr. Wach is currently one of the chairmen of IDS.

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