The Benefits of Natural Products for Neurodegenerative Diseases

1. Front Matter

   Pages i-xii

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2. Epigenetic Modifications in Neurological Diseases: Natural Products as Epigenetic Modulators a Treatment Strategy

   • Omkaram Gangisetty, Sengottuvelan Murugan

   Pages 1-25

3. Effect of Docosahexaenoic Acid (DHA) on Spinal Cord Injury

   • Sreyashi Samaddar

   Pages 27-39

4. Dietary Polyphenols as Potential Remedy for Dementia

   • Abhishek Desai

   Pages 41-56

5. Spices: Potential Therapeutics for Alzheimer’s Disease

   • N. Satheeshkumar, R. S. K. Vijayan, A. Lingesh, S. Santhikumar, Ch. Vishnuvardhan

   Pages 57-78

6. Application of Bioactive Compounds from Scutellaria in Neurologic Disorders

   • Farhan Hussain, Sandeep Mittal, Nirmal Joshee, Prahlad Parajuli

   Pages 79-94

7. Alzheimer’s Disease and Medicinal Plants: An Overview

   • S. Manoharan, M. Mohamed Essa, A. Vinoth, R. Kowsalya, A. Manimaran, R. Selvasundaram

   Pages 95-105

8. Efficacy of Natural Compounds in Neurodegenerative Disorders

   • Pranay Srivastava, Rajesh Singh Yadav

   Pages 107-123

9. Impact of Non-Enzymatic Glycation in Neurodegenerative Diseases: Role of Natural Products in Prevention

   • Saheem Ahmad, Mohammed Farhan

   Pages 125-151

10. Role of Plant Polyphenols in Alzheimer’s Disease

    • Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa

    Pages 153-171

11. Cannabinoids: Glutamatergic Transmission and Kynurenines

    • Ana Laura Colín-González, Gabriela Aguilera, Abel Santamaría

    Pages 173-198

12. Carotenoids and Neurobiological Health

    • J. Guest, R. Grant

    Pages 199-228

13. Role of Quercetin Benefits in Neurodegeneration

    • Preetham Elumalai, Sreeja Lakshmi

    Pages 229-245

14. Role of Omega-3 PUFAs in Neurobiological Health

    • R. Grant, J. Guest

    Pages 247-274

15. Neuroprotective Activities of Saffron and Crocin

    • Shinji Soeda, Kosuke Aritake, Yoshihiro Urade, Hiroshi Sato, Yukihiro Shoyama

    Pages 275-292

16. The Advances in Neurobiology

    • M. Ishwarya, R. T. Narendhirakannan

    Pages 293-306

17. Brain Food at High Altitude

    • Vishal Jain

    Pages 307-321

18. Indian Herbs for the Treatment of Neurodegenerative Disease

    • Padmanabhan Mannangatti, Kamalakkannan Narasimha Naidu

    Pages 323-336

19. Avocado as a Major Dietary Source of Antioxidants and Its Preventive Role in Neurodegenerative Diseases

    • Kalandar Ameer

    Pages 337-354

20. Detoxification of Carbonyl Compounds by Carbonyl Reductase in Neurodegeneration

    • Mohammad Abdur Rashid, Mahmuda Haque, Mohammed Akbar

    Pages 355-365

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural productsand edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

• Alzheimer's disease
• brain function
• fruits
• natural products
• neurodegenerative diseases
• vegetables

“This is a collection of papers on the use of natural products for a variety of neurodegenerative diseases. The purpose is to validate the use of natural products for the treatment of neurodegenerative diseases. The objectives are worthy as there is a need for clinicians and researchers to consider the value of safer natural products for treatment. … written primarily for researchers, but it is also useful for clinicians. It is an attempt to spur further research into natural products.” (Paul Joseph Ratte, Doody's Book Reviews, December, 2016)

• Food Science and Nutrition College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman

  M. Mohamed Essa

• National Institutes of Health, National Institute on Alcohol Abuse, Rockville, USA

  Mohammed Akbar

• Australian School of Advanced Medicine, Macquarie University, Sydney, Australia

  Gilles Guillemin

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