Overview
- Discusses current models of how the B cell antigen receptor becomes activated
- Focusses on the elucidation of intracellular B cell receptor signaling pathways
- Describes modulation of B cell activation by coreceptors and under disease conditions
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 393)
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Table of contents (10 chapters)
Keywords
About this book
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.
Editors and Affiliations
About the editors
Bibliographic Information
Book Title: B Cell Receptor Signaling
Editors: Tomohiro Kurosaki, Jürgen Wienands
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-26133-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-26131-7Published: 06 January 2016
Softcover ISBN: 978-3-319-79899-8Published: 30 March 2018
eBook ISBN: 978-3-319-26133-1Published: 26 December 2015
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: X, 231
Topics: Immunology, Molecular Medicine, Cancer Research