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Antimicrobial Peptides

Role in Human Health and Disease

  • Book
  • © 2016

Overview

Editors:
  1. Jürgen Harder

    1. Department of Dermatology, University-Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

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  2. Jens-M. Schröder

    1. Department of Dermatology, University-Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

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  • Presents state-of-the-art of research on antimicrobial peptides in human medicine
  • Elucidates the immunomodulatory aspects of AMP
  • Discusses the potential therapeutic use of AMP

Part of the book series: Birkhäuser Advances in Infectious Diseases (BAID)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-vi
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  2. Antimicrobial Peptides in Cutaneous Wound Healing

    • Ole E. Sørensen
    Pages 1-15

  3. Antimicrobial Peptides as Endogenous Antibacterials and Antivirals at the Ocular Surface

    • Fabian Garreis, Martin Schicht, Friedrich Paulsen
    Pages 17-32

  4. Function of Antimicrobial Peptides in Lung Innate Immunity

    • Frederik Seiler, Robert Bals, Christoph Beisswenger
    Pages 33-52

  5. Antimicrobial Peptides: Maintaining Sterility of the Urinary Tract

    • Brian Becknell, John David Spencer
    Pages 53-65

  6. Antimicrobial Peptides in the Gut

    • Maureen J. Ostaff, Eduard F. Stange, Jan Wehkamp
    Pages 67-88

  7. Metal Sequestration: An Important Contribution of Antimicrobial Peptides to Nutritional Immunity

    • Steven Damo, Thomas E. Kehl-Fie
    Pages 89-100

  8. Regulation of Antimicrobial Peptide Gene Expression by Vitamin D

    • Adrian F. Gombart
    Pages 101-113

  9. Dichotomous Roles of Cationic Polypeptides Targeting HIV

    • Alexander M. Cole, Amy Liese Cole
    Pages 115-127

  10. Antimicrobial Peptides in Host Defense: Functions Beyond Antimicrobial Activity

    • Kim Alan Brogden, Amber M. Bates, Carol L. Fischer
    Pages 129-146

  11. Antimicrobial Peptides: Do They Have a Future as Therapeutics?

    • Michael Zasloff
    Pages 147-154

  12. Back Matter

    Pages 155-158
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Keywords

About this book

This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.

Editors and Affiliations

  • Department of Dermatology, University-Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

    Jürgen Harder, Jens-M. Schröder

Bibliographic Information

  • Book Title: Antimicrobial Peptides

  • Book Subtitle: Role in Human Health and Disease

  • Editors: Jürgen Harder, Jens-M. Schröder

  • Series Title: Birkhäuser Advances in Infectious Diseases

  • DOI: https://doi.org/10.1007/978-3-319-24199-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-24197-5Published: 08 January 2016

  • Softcover ISBN: 978-3-319-79588-1Published: 30 March 2018

  • eBook ISBN: 978-3-319-24199-9Published: 24 December 2015

  • Series ISSN: 2504-3811

  • Series E-ISSN: 2504-3838

  • Edition Number: 1

  • Number of Pages: VI, 158

  • Number of Illustrations: 10 illustrations in colour

  • Topics: Immunology, Microbiology

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