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Medullary Thyroid Carcinoma

Biology – Management – Treatment

  • Book
  • © 2015

Overview

Editors:
  1. Friedhelm Raue

    1. Endocrine Practice and Molecular Laboratory, Medical Faculty, University of Heidelberg , Heidelberg, Germany

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  • Provides a comprehensive overview on the different forms of medullary thyroid carcinoma and their management
  • Describes the role of calcitonin and other tumor markers
  • Explains the use of thyroidectomy and tyrosine kinase inhibitors
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 204)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Thyroid C-Cell Biology and Oncogenic Transformation

    • Gilbert J. Cote, Elizabeth G. Grubbs, Marie-Claude Hofmann
    Pages 1-39

  3. Histopathology of C Cells and Medullary Thyroid Carcinoma

    • Kurt Werner Schmid
    Pages 41-60

  4. Epidemiology and Clinical Presentation of Medullary Thyroid Carcinoma

    • Friedhelm Raue, Karin Frank-Raue
    Pages 61-90

  5. Medullary Thyroid Carcinoma: Imaging

    • Stefan Delorme, Friedhelm Raue
    Pages 91-116

  6. Calcitonin as Biomarker for the Medullary Thyroid Carcinoma

    • Yoon Ju Bae, Michael Schaab, Juergen Kratzsch
    Pages 117-137

  7. Hereditary Medullary Thyroid Cancer Genotype–Phenotype Correlation

    • Karin Frank-Raue, Friedhelm Raue
    Pages 139-156

  8. Pheochromocytomas in Multiple Endocrine Neoplasia Type 2

    • Venessa H. M. Tsang, Lyndal J. Tacon, Diana L. Learoyd, Bruce G. Robinson
    Pages 157-178

  9. Primary Hyperparathyroidism in MEN2 Syndromes

    • Maria Alevizaki, Katerina Saltiki
    Pages 179-186

  10. Surgical Treatment of Medullary Thyroid Cancer

    • Andreas Machens, Henning Dralle
    Pages 187-205

  11. Long-Term Follow-up in Medullary Thyroid Carcinoma

    • Friedhelm Raue, Karin Frank-Raue
    Pages 207-225

  12. Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma

    • Ramona Dadu, Mimi N. Hu, Elizabeth G. Grubbs, Robert F. Gagel
    Pages 227-249
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Keywords

About this book

This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Editors and Affiliations

  • Endocrine Practice and Molecular Laboratory, Medical Faculty, University of Heidelberg , Heidelberg, Germany

    Friedhelm Raue

Bibliographic Information

  • Book Title: Medullary Thyroid Carcinoma

  • Book Subtitle: Biology – Management – Treatment

  • Editors: Friedhelm Raue

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-319-22542-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-22541-8Published: 04 November 2015

  • Softcover ISBN: 978-3-319-36260-1Published: 23 August 2016

  • eBook ISBN: 978-3-319-22542-5Published: 22 October 2015

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: VIII, 249

  • Topics: Oncology, Endocrinology, Human Genetics, Nuclear Medicine

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